Antioxidant, Antihyperglycemic, and Antihyperlipidemic Properties of S. Y. Hu Leaves in Experimental Animals: Modulation of Thioredoxin and Glutathione Systems, Renal Water Reabsorption, and Gut Microbiota

Overview

Journal Front Nutr

Specialty Nutritional Sciences

Date 2023 May 15

PMID 37187875

Authors

Ruixia Dong

Junjie Pan

Guangshan Zhao

Qiuyan Zhao

Shiqiong Wang

Ning Li

Lianjun Song

Xianqing Huang

Shuxing Miao

Junhui Ying

Fangying Wu

Dongxu Wang

Kejun Cheng

Daniel Granato

Qiuyan Ban

Affiliations

Soon will be listed here.

Abstract

Introduction: Excessive calorie intake and physical inactivity have dramatically increased nutrient overload-associated disease, becoming a global public health issue. S. Y. Hu () is a homology plant of food and medicine in China and shows several health benefits.

Methods: This work investigated the antioxidant activity, the alleviating effects, and the mechanism of action on diabetes and hyperlipidemia of leaves.

Results And Discussion: Results showed that leaves infusion displayed antioxidant activity measured by ABTS and ferric reducing antioxidant power methods. In wild-type Kunming mice, leaves infusion consumption activated the hepatic antioxidant enzymes, including glutathione reductase, glutathione -transferase, glutathione peroxidase and thioredoxin reductase as well as thioredoxin reductase 1. In alloxan-induced type 1 diabetic mice, leaves infusion ameliorated diabetic symptoms, including polyuria, polydipsia, polyphagia and hyperglycemia, in a dose-dependent and time-course manners. The mechanism involved leaves up-regulating renal water reabsorption associated protein - urine transporter A1-and promoting the trafficking of urine transporter A1 and aquaporin 2 to the apical plasma membrane. Despite this, in high-fat diet-induced hyperlipidemic golden hamsters, leaves powder did not significantly effect on hyperlipidemia and body weight gain. This might be attributed to leaves powder increasing the calorie intake. Interestingly, we found that leaves extract containing a lower dose of total flavonoid than leaves powder pronouncedly reduced the levels of total cholesterol, triglyceride, and low-density lipoprotein cholesterol in serum in golden hamsters fed a high-fat diet. Furthermore, leaves extract elevated the diversity of gut microbiota and the abundance of and It also decreased the abundance of at the genus level in golden hamsters fed a high-fat diet. Overall, leaves benefit oxidative stress prevention and metabolic syndrome amelioration

References

Santos J, Deolindo C, Esmerino L, Genovese M, Fujita A, Marques M . Effects of time and extraction temperature on phenolic composition and functional properties of red rooibos (Aspalathus linearis). Food Res Int. 2017; 89(Pt 1):476-487. DOI: 10.1016/j.foodres.2016.08.041. View

Rahayu E, Mariyatun M, Manurung N, Hasan P, Therdtatha P, Mishima R . Effect of probiotic Dad-13 powder consumption on the gut microbiota and intestinal health of overweight adults. World J Gastroenterol. 2021; 27(1):107-128. PMC: 7789061. DOI: 10.3748/wjg.v27.i1.107. View

Li Z, Jia R, Wu J, Lin L, Ou Z, Liao B . Sargassum fusiforme polysaccharide partly replaces acarbose against type 2 diabetes in rats. Int J Biol Macromol. 2020; 170:447-458. DOI: 10.1016/j.ijbiomac.2020.12.126. View

Wang N, Liu X, Li J, Zhang Q, Li X, An Q . Antibacterial mechanism of the synergistic combination between streptomycin and alcohol extracts from the Chimonanthus salicifolius S. Y. Hu. leaves. J Ethnopharmacol. 2019; 250:112467. DOI: 10.1016/j.jep.2019.112467. View

Klein J, Sands J, Qian L, Wang X, Yang B . Upregulation of urea transporter UT-A2 and water channels AQP2 and AQP3 in mice lacking urea transporter UT-B. J Am Soc Nephrol. 2004; 15(5):1161-7. DOI: 10.1097/01.asn.0000125617.19799.72. View

Beltowski J, Rachanczyk J, Wlodarczyk M . Thiazolidinedione-induced fluid retention: recent insights into the molecular mechanisms. PPAR Res. 2013; 2013:628628. PMC: 3614122. DOI: 10.1155/2013/628628. View

Bardoux P, Ahloulay M, Le Maout S, Bankir L, Trinh-Trang-Tan M . Aquaporin-2 and urea transporter-A1 are up-regulated in rats with type I diabetes mellitus. Diabetologia. 2001; 44(5):637-45. DOI: 10.1007/s001250051671. View

Caturano A, Galiero R, Pafundi P . Metformin for Type 2 Diabetes. JAMA. 2019; 322(13):1312. DOI: 10.1001/jama.2019.11489. View

Wei Y, Chen P, Ling T, Wang Y, Dong R, Zhang C . Certain (-)-epigallocatechin-3-gallate (EGCG) auto-oxidation products (EAOPs) retain the cytotoxic activities of EGCG. Food Chem. 2016; 204:218-226. DOI: 10.1016/j.foodchem.2016.02.134. View

10.

Wu X, Zhao G, He Y, Wang W, Yang C, Zhang J . Pharmacological mechanisms of the anticancer action of sodium selenite against peritoneal cancer in mice. Pharmacol Res. 2019; 147:104360. DOI: 10.1016/j.phrs.2019.104360. View

11.

Zhou B, Liu S, Li M, Chen Z, Wang P, Cheng D . Study on quality standards for Chimonanthus nitens. Genet Mol Res. 2016; 15(3). DOI: 10.4238/gmr.15038984. View

12.

Trigona W, Mullarky I, Cao Y, Sordillo L . Thioredoxin reductase regulates the induction of haem oxygenase-1 expression in aortic endothelial cells. Biochem J. 2005; 394(Pt 1):207-16. PMC: 1386018. DOI: 10.1042/BJ20050712. View

13.

Zhang X, Xu P, Lin B, Deng X, Zhu J, Chen X . attenuated vascular remodeling by alleviating endoplasmic reticulum stress in spontaneously hypertensive rats. Food Funct. 2022; 13(11):6293-6305. DOI: 10.1039/d1fo04381a. View

14.

Huang F, Zheng X, Ma X, Jiang R, Zhou W, Zhou S . Theabrownin from Pu-erh tea attenuates hypercholesterolemia via modulation of gut microbiota and bile acid metabolism. Nat Commun. 2019; 10(1):4971. PMC: 6823360. DOI: 10.1038/s41467-019-12896-x. View

15.

Huang J, Li S, Wang Q, Guan X, Qian L, Li J . Pediococcus pentosaceus B49 from human colostrum ameliorates constipation in mice. Food Funct. 2020; 11(6):5607-5620. DOI: 10.1039/d0fo00208a. View

16.

Zhao G, Wu X, Chen P, Zhang L, Yang C, Zhang J . Selenium nanoparticles are more efficient than sodium selenite in producing reactive oxygen species and hyper-accumulation of selenium nanoparticles in cancer cells generates potent therapeutic effects. Free Radic Biol Med. 2018; 126:55-66. DOI: 10.1016/j.freeradbiomed.2018.07.017. View

17.

Ferrannini G, Hach T, Crowe S, Sanghvi A, Hall K, Ferrannini E . Energy Balance After Sodium-Glucose Cotransporter 2 Inhibition. Diabetes Care. 2015; 38(9):1730-5. PMC: 4542276. DOI: 10.2337/dc15-0355. View

18.

Marin L, Miguelez E, Villar C, Lombo F . Bioavailability of dietary polyphenols and gut microbiota metabolism: antimicrobial properties. Biomed Res Int. 2015; 2015:905215. PMC: 4352739. DOI: 10.1155/2015/905215. View

19.

Takahashi T, Tabuchi T, Tamaki Y, Kosaka K, Takikawa Y, Satoh T . Carnosic acid and carnosol inhibit adipocyte differentiation in mouse 3T3-L1 cells through induction of phase2 enzymes and activation of glutathione metabolism. Biochem Biophys Res Commun. 2009; 382(3):549-54. DOI: 10.1016/j.bbrc.2009.03.059. View

20.

Cheng Y, Wu C, Ho C, Yen G . Catechin protects against ketoprofen-induced oxidative damage of the gastric mucosa by up-regulating Nrf2 in vitro and in vivo. J Nutr Biochem. 2012; 24(2):475-83. DOI: 10.1016/j.jnutbio.2012.01.010. View