Multiple Functions and Regulatory Network of MiR-150 in B Lymphocyte-related Diseases

Overview

Journal Front Oncol

Specialty Oncology

Date 2023 May 14

PMID 37182123

Authors

Yue-Zi Hu

Qiao Li

Peng-Fei Wang

Xue-Ping Li

Zhao-Lan Hu

Affiliations

Soon will be listed here.

Abstract

MicroRNAs (miRNAs) play vital roles in the post-transcriptional regulation of gene expression. Previous studies have shown that miR-150 is a crucial regulator of B cell proliferation, differentiation, metabolism, and apoptosis. miR-150 regulates the immune homeostasis during the development of obesity and is aberrantly expressed in multiple B-cell-related malignant tumors. Additionally, the altered expression of MIR-150 is a diagnostic biomarker of various autoimmune diseases. Furthermore, exosome-derived miR-150 is considered as prognostic tool in B cell lymphoma, autoimmune diseases and immune-mediated disorders, suggesting miR-150 plays a vital role in disease onset and progression. In this review, we summarized the miR-150-dependent regulation of B cell function in B cell-related immune diseases.

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