The Ion Channels and Transporters Gene Expression Profile Indicates a Shift in Excitability and Metabolisms During Malignant Progression of Follicular Lymphoma

Overview

Journal Sci Rep

Specialty Science

Date 2019 Jun 15

PMID 31197180

Citations 14

Authors

Alberto Magi

Marika Masselli

Cesare Sala

Angela Guerriero

Pasquale Laise

Benedetta Puccini

Luigi Rigacci

Carla Breschi

Olivia Crociani

Serena Pillozzi

Annarosa Arcangeli

Affiliations

Soon will be listed here.

Abstract

The definition of the gene expression profile of genes encoding Ion Channels and Transporters (ICT-GEP) represents a novel and attracting aspect in cancer. We determined the ICT-GEP of Follicular Lymphoma (FL), and compared it with that of the more aggressive Diffuse Large B Cell Lymphoma (DLBCL). cDNA microarray data were collected both from patients enrolled for this study, and from public datasets. In FL the ICT-GEP indicated the overexpression of both the K channel encoding gene KCNN4, and SLC2A1, which encodes the Glut1 glucose transporter. SLC2A1 turned out to represent the hub of a functional network, connecting channels and transporters in FL. Relapsed FL patients were characterised by 38 differentially expressed ICT genes, among which ATP9A, SLC2A1 and KCNN4 were under-expressed, indicating a down-regulation of both excitability and glycolysis. A completely different profile of K channel encoding genes emerged in DLBCL accompanied by the over-expression of the fatty acid transporter-encoding gene SLC27A1 as well as of the metabolism regulator NCoR1. This indicates a change in excitability and a shift towards an oxidative metabolism in DLBCL. Overall, the ICT-GEP may contribute to identifying novel lymphoma biomarkers related to excitability and metabolic pathways, with particular relevance for drug resistant, relapsed FL.

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