Pancreatic Juice Cytology Evaluations Using Synthetic Secretin and Serial Pancreatic Juice Aspiration Cytological Examination for the Diagnosis of Pancreatic Ductal Adenocarcinoma

Overview

Journal Diagnostics (Basel)

Specialty Radiology

Date 2023 May 13

PMID 37174928

Authors

Yohei Takeda

Kazuya Matsumoto

Takumi Onoyama

Taro Yamashita

Hiroki Koda

Wataru Hamamoto

Yuri Sakamoto

Takuya Shimosaka

Shiho Kawahara

Yuta Seki

Hiroki Kurumi

Yasushi Horie

Hajime Isomoto

Naoyuki Yamaguchi

Affiliations

Soon will be listed here.

Abstract

Pathological examination by endoscopic ultrasound-fine needle aspiration is not possible in approximately 10% of pancreatic tumor cases. Pancreatic juice cytology (PJC) is considered an alternative diagnostic method. However, its diagnostic capability is insufficient, and PJC has been repeatedly redevised. Serial pancreatic juice aspiration cytological examination (SPACE) and secretin-loaded PJC (S-PJC) have been recently introduced as alternative diagnostic methods. This study aimed to determine the diagnostic capacity and safety of SPACE and S-PJC using a propensity score-matched analysis. The sensitivity, specificity, and accuracy were 75.0%, 100%, and 92.3% for S-PJC, respectively, and 71.4%, 100%, and 92.3% for SPACE, respectively, meaning that there was no significant difference between the groups. Four patients (15.4%) each in the S-PJC and SPACE groups experienced complications, including postendoscopic retrograde cholangiopancreatography, pancreatitis, and cholangitis. Overall, there was no difference in efficacy and safety between the SPACE and S-PJC groups.

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