Duration of Ischemia Influences the Development and Resolution of Ischemic Brain Edema

Overview

Journal Stroke

Specialties Cardiology & Vascular Diseases
Neurology

Date 1986 May 1

PMID 3715944

Citations 18

Authors

N V Todd

P Picozzi

A Crockard

R W RUSSELL

Affiliations

Soon will be listed here.

Abstract

The influence of the duration of ischemia on the development and resolution of post-ischemic brain edema (SG method) was studied in anesthetized rats. Edema developed during ischemia and the amount of edema was related to the duration of ischemia (r = 0.843, p less than 0.001). With recirculation to three hours, the major determinant of the amount of edema was still the duration of the preceding ischemia (p less than 0.001). Resolution of brain edema only occurred following fifteen minutes ischemia. Post-ischemic blood-brain barrier breakdown (14C-AIB, EB albumin) was greatest following longer ischemia. Where present, the BBB leakage was simultaneously to large and small molecules.

Citing Articles

Early Edema Within the Ischemic Core Is Time-Dependent and Associated With Functional Outcomes of Acute Ischemic Stroke Patients.

Han Q, Yang J, Gao X, Li J, Wu Y, Xu Y Front Neurol. 2022; 13:861289.

PMID: 35463133 PMC: 9021998. DOI: 10.3389/fneur.2022.861289.

MicroRNA-210 Suppresses Junction Proteins and Disrupts Blood-Brain Barrier Integrity in Neonatal Rat Hypoxic-Ischemic Brain Injury.

Ma Q, Dasgupta C, Li Y, Huang L, Zhang L Int J Mol Sci. 2017; 18(7).

PMID: 28672801 PMC: 5535849. DOI: 10.3390/ijms18071356.

Imaging of cerebral ischemic edema and neuronal death.

von Kummer R, Dzialowski I Neuroradiology. 2017; 59(6):545-553.

PMID: 28540400 DOI: 10.1007/s00234-017-1847-6.

Imaging Findings Associated with Space-Occupying Edema in Patients with Large Middle Cerebral Artery Infarcts.

Horsch A, Dankbaar J, Stemerdink T, Bennink E, van Seeters T, Kappelle L AJNR Am J Neuroradiol. 2016; 37(5):831-7.

PMID: 26797136 PMC: 7960291. DOI: 10.3174/ajnr.A4637.

Human Data Supporting Glyburide in Ischemic Stroke.

Sheth K, Simard J, Elm J, Kronenberg G, Kunte H, Kimberly W Acta Neurochir Suppl. 2015; 121:13-8.

PMID: 26463916 PMC: 5189719. DOI: 10.1007/978-3-319-18497-5_3.