Ferroptosis-associated Circular RNAs: Opportunities and Challenges in the Diagnosis and Treatment of Cancer

Overview

Journal Front Cell Dev Biol

Specialty Cell Biology

Date 2023 May 8

PMID 37152286

Authors

Ruotong Yang

Liwei Ma

Junhu Wan

Zhuofang Li

Zhengwu Yang

Zhuochen Zhao

Liang Ming

Affiliations

Soon will be listed here.

Abstract

Ferroptosis is an emerging form of non-apoptotic regulated cell death which is different from cell death mechanisms such as autophagy, apoptosis and necrosis. It is characterized by iron-dependent lipid peroxide accumulation. Circular RNA (circRNA) is a newly studied evolutionarily conserved type of non-coding RNA with a covalent closed-loop structure. It exhibits universality, conservatism, stability and particularity. At present, the functions that have been studied and found include microRNA sponge, protein scaffold, transcription regulation, translation and production of peptides, etc. CircRNA can be used as a biomarker of tumors and is a hotspot in RNA biology research. Studies have shown that ferroptosis can participate in tumor regulation through the circRNA molecular pathway and then affect cancer progression, which may become a direction of cancer diagnosis and treatment in the future. This paper reviews the molecular biological mechanism of ferroptosis and the role of circular RNA in tumors and summarizes the circRNA related to ferroptosis in tumors, which may inspire research prospects for the precise prevention and treatment of cancer in the future.

Citing Articles

Ferroptosis and circular RNAs: new horizons in cancer therapy.

Bhat A, Kukreti N, Afzal M, Goyal A, Thapa R, Ali H EXCLI J. 2024; 23:570-599.

PMID: 38887390 PMC: 11180955. DOI: 10.17179/excli2024-7005.

Exploring the Role of Ferroptosis-Related Circular RNAs in Subarachnoid Hemorrhage.

Song Y, Luo X, Yao L, Chen Y, Mao X Mol Biotechnol. 2024; .

PMID: 38619799 DOI: 10.1007/s12033-024-01140-7.

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