Heterogeneity and Versatility of the Extracellular Matrix During the Transition from Pleomorphic Adenoma to Carcinoma Ex Pleomorphic Adenoma: Cumulative Findings from Basic Research and New Insights

Overview

Journal Front Oral Health

Date 2023 May 4

PMID 37138857

Authors

Joao Figueira Scarini

Reydson Alcides de Lima-Souza

Luccas Lavareze

Maria Clara Falcao Ribeiro de Assis

Ingrid Iara Damas

Albina Altemani

Erika Said Abu Egal

Jean Nunes Dos Santos

Ibrahim Olajide Bello

Fernanda Viviane Mariano

Affiliations

Soon will be listed here.

Abstract

Pleomorphic adenoma (PA) is the most common salivary gland tumor, accounting for 50%-60% of these neoplasms. If untreated, 6.2% of PA may undergo malignant transformation to carcinoma ex-pleomorphic adenoma (CXPA). CXPA is a rare and aggressive malignant tumor, whose prevalence represents approximately 3%-6% of all salivary gland tumors. Although the pathogenesis of the PA-CXPA transition remains unclear, CXPA development requires the participation of cellular components and the tumor microenvironment for its progression. The extracellular matrix (ECM) comprises a heterogeneous and versatile network of macromolecules synthesized and secreted by embryonic cells. In the PA-CXPA sequence, ECM is formed by a variety of components including collagen, elastin, fibronectin, laminins, glycosaminoglycans, proteoglycans, and other glycoproteins, mainly secreted by epithelial cells, myoepithelial cells, cancer-associated fibroblasts, immune cells, and endothelial cells. Like in other tumors including breast cancer, ECM changes play an important role in the PA-CXPA sequence. This review summarizes what is currently known about the role of ECM during CXPA development.

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