Association Between Periodontitis and Osteoporosis in United States Adults from the National Health and Nutrition Examination Survey: a Cross-sectional Analysis

Overview

Journal BMC Oral Health

Publisher Biomed Central

Specialty Dentistry

Date 2023 May 2

PMID 37131215

Authors

Jing Peng

Jianming Chen

Yucheng Liu

Jun Lyu

Bin Zhang

Affiliations

Soon will be listed here.

Abstract

Objective: This cross-sectional study aimed to investigate the association between periodontitis and osteoporosis among US adults as well as the subgroup of menopausal women.

Background: Periodontitis and osteoporosis are both chronic inflammatory diseases characterized by local or systemic bone resorption. Since they share many risk factors, and the significant decrease in estrogen along with menopause is unfavorable for both diseases, it's reasonable to assume that there exists some links between the two diseases, especially during the menopause.

Methods: We analyzed data from the National Health and Nutrition Examination Survey (NHANES) 2009-2010 and 2013-2014. Periodontitis (defined according to the CDC/AAP definition) and osteoporosis (assessed by the dual-energy radiation absorptiometry) data were available for 5736 participants, and 519 subjects were enrolled in the subgroup of menopausal women aged 45-60 years old. We used binary logistic regression analysis to examine the association between the two diseases both in crude and fully adjusted model.

Results: In the fully adjusted model, osteoporosis was significantly associated with an increased risk of periodontal disease (OR:1.66, 95% CI: 1.00-2.77) in the whole population. As to the subgroup of menopausal women, osteoporosis group had an adjusted OR of 9.66 (95% CI: 1.13-82.38) for developing severe periodontitis in the fully adjusted model.

Conclusions: Osteoporosis is significantly associated with periodontitis and the association is even more pronounced in menopausal women with severe periodontitis.

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References

Cheng C, Chen L, Chen K . Osteoporosis Due to Hormone Imbalance: An Overview of the Effects of Estrogen Deficiency and Glucocorticoid Overuse on Bone Turnover. Int J Mol Sci. 2022; 23(3). PMC: 8836058. DOI: 10.3390/ijms23031376. View

Hwang S, Park S . The relationship between depression and periodontal diseases. Community Dent Health. 2018; 35(1):23-29. DOI: 10.1922/CDH_4150Hwang07. View

Eke P, Dye B, Wei L, Thornton-Evans G, Genco R . Prevalence of periodontitis in adults in the United States: 2009 and 2010. J Dent Res. 2012; 91(10):914-20. DOI: 10.1177/0022034512457373. View

ALHarthi S, Natto Z, Midle J, Gyurko R, ONeill R, Steffensen B . Association between time since quitting smoking and periodontitis in former smokers in the National Health and Nutrition Examination Surveys (NHANES) 2009 to 2012. J Periodontol. 2018; 90(1):16-25. DOI: 10.1002/JPER.18-0183. View

Passos-Soares J, Vianna M, Gomes-Filho I, Cruz S, Barreto M, Adan L . Association between osteoporosis treatment and severe periodontitis in postmenopausal women. Menopause. 2017; 24(7):789-795. DOI: 10.1097/GME.0000000000000830. View

Wang C, McCauley L . Osteoporosis and Periodontitis. Curr Osteoporos Rep. 2016; 14(6):284-291. PMC: 5654540. DOI: 10.1007/s11914-016-0330-3. View

Romandini M, Shin H, Romandini P, Lafori A, Cordaro M . Hormone-related events and periodontitis in women. J Clin Periodontol. 2020; 47(4):429-441. DOI: 10.1111/jcpe.13248. View

Minkin M . Menopause: Hormones, Lifestyle, and Optimizing Aging. Obstet Gynecol Clin North Am. 2019; 46(3):501-514. DOI: 10.1016/j.ogc.2019.04.008. View

Bartold P . Lifestyle and periodontitis: The emergence of personalized periodontics. Periodontol 2000. 2018; 78(1):7-11. DOI: 10.1111/prd.12237. View

10.

Ren Z, Hu C, He H, Li Y, Lyu J . Global and regional burdens of oral cancer from 1990 to 2017: Results from the global burden of disease study. Cancer Commun (Lond). 2020; 40(2-3):81-92. PMC: 7163731. DOI: 10.1002/cac2.12009. View

11.

Jain S, Rogier K, Prouty L, Jain S . Protective effects of 17beta-estradiol and trivalent chromium on interleukin-6 secretion, oxidative stress, and adhesion of monocytes: relevance to heart disease in postmenopausal women. Free Radic Biol Med. 2004; 37(11):1730-5. DOI: 10.1016/j.freeradbiomed.2004.08.003. View

12.

Kassebaum N, Bernabe E, Dahiya M, Bhandari B, Murray C, Marcenes W . Global burden of severe periodontitis in 1990-2010: a systematic review and meta-regression. J Dent Res. 2014; 93(11):1045-53. PMC: 4293771. DOI: 10.1177/0022034514552491. View

13.

Grodstein F, Colditz G, Stampfer M . Post-menopausal hormone use and tooth loss: a prospective study. J Am Dent Assoc. 1996; 127(3):370-7, quiz 392. DOI: 10.14219/jada.archive.1996.0208. View

14.

van Hamburg J, Asmawidjaja P, Davelaar N, Mus A, Cornelissen F, van Leeuwen J . TNF blockade requires 1,25(OH)2D3 to control human Th17-mediated synovial inflammation. Ann Rheum Dis. 2012; 71(4):606-12. DOI: 10.1136/annrheumdis-2011-200424. View

15.

Yang J, Li Y, Liu Q, Li L, Feng A, Wang T . Brief introduction of medical database and data mining technology in big data era. J Evid Based Med. 2020; 13(1):57-69. PMC: 7065247. DOI: 10.1111/jebm.12373. View

16.

Marjanovic E, Southern H, Coates P, Adams J, Walsh T, Horner K . Do patients with osteoporosis have an increased prevalence of periodontal disease? A cross-sectional study. Osteoporos Int. 2013; 24(7):1973-9. DOI: 10.1007/s00198-012-2246-9. View

17.

Eke P, Page R, Wei L, Thornton-Evans G, Genco R . Update of the case definitions for population-based surveillance of periodontitis. J Periodontol. 2012; 83(12):1449-54. PMC: 6005373. DOI: 10.1902/jop.2012.110664. View

18.

Martinez-Maestre M, Gonzalez-Cejudo C, Machuca G, Torrejon R, Castelo-Branco C . Periodontitis and osteoporosis: a systematic review. Climacteric. 2010; 13(6):523-9. DOI: 10.3109/13697137.2010.500749. View

19.

Rosano G, Vitale C, Marazzi G, Volterrani M . Menopause and cardiovascular disease: the evidence. Climacteric. 2007; 10 Suppl 1:19-24. DOI: 10.1080/13697130601114917. View

20.

Rosen C, Adams J, Bikle D, Black D, Demay M, Manson J . The nonskeletal effects of vitamin D: an Endocrine Society scientific statement. Endocr Rev. 2012; 33(3):456-92. PMC: 3365859. DOI: 10.1210/er.2012-1000. View