Glucose Partitioning in the Bone Marrow Micro-environment in Acute Myeloid Leukaemia

Overview

Journal Leukemia

Specialties Hematology
Oncology

Date 2023 Apr 29

PMID 37120691

Authors

Suqi Deng

Juan Du

Robert Peter Gale

Lu Wang

Huien Zhan

Fangshu Liu

Kexiu Huang

Hao Xu

Hui Zeng

Affiliations

Soon will be listed here.

Abstract

Acute myeloid leukaemia (AML) cells metabolise glucose by glycolysis-based re-programming. However, how glucose uptake is partitioned between leukaemia cells and other cells of the bone marrow micro-environment is unstudied. We used a positron emission tomography (PET) tracer F fluorodeoxyglucose ([F]-FDG) probe and transcriptomic analyses to detect glucose uptake by diverse cells in the bone marrow micro-environment in a MLL-AF9-induced mouse model. Leukaemia cells had the greatest glucose uptake with leukaemia stem and progenitor cells having the greatest glucose uptake. We also show the effects of anti-leukaemia drugs on leukaemia cell numbers and glucose uptake. Our data suggest targeting glucose uptake as a potential therapy strategy in AML if our observations are validated in humans with AML.

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