Healthy Aging and Muscle Function Are Positively Associated with NAD Abundance in Humans

Overview

Journal Nat Aging

Specialty Geriatrics

Date 2023 Apr 28

PMID 37118369

Authors

Georges E Janssens

Lotte Grevendonk

Ruben Zapata Perez

Bauke V Schomakers

Johan De Vogel-Van Den Bosch

Jan M W Geurts

Michel van Weeghel

Patrick Schrauwen

Riekelt H Houtkooper

Joris Hoeks

Affiliations

Soon will be listed here.

Abstract

Skeletal muscle is greatly affected by aging, resulting in a loss of metabolic and physical function. However, the underlying molecular processes and how (lack of) physical activity is involved in age-related metabolic decline in muscle function in humans is largely unknown. Here, we compared, in a cross-sectional study, the muscle metabolome from young to older adults, whereby the older adults were exercise trained, had normal physical activity levels or were physically impaired. Nicotinamide adenine dinucleotide (NAD) was one of the most prominent metabolites that was lower in older adults, in line with preclinical models. This lower level was even more pronounced in impaired older individuals, and conversely, exercise-trained older individuals had NAD levels that were more similar to those found in younger individuals. NAD abundance positively correlated with average number of steps per day and mitochondrial and muscle functioning. Our work suggests that a clear association exists between NAD and health status in human aging.

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