Thrombospondin-2 Acts As a Critical Regulator of Cartilage Regeneration: A Review

Overview

Journal Medicine (Baltimore)

Specialty General Medicine

Date 2023 Apr 28

PMID 37115081

Authors

Jing Niu

Yanli Liu

Junjun Wang

Hui Wang

Ying Zhao

Min Zhang

Affiliations

Soon will be listed here.

Abstract

The degeneration of articular cartilage tissue is the most common cause of articular cartilage diseases such as osteoarthritis. There are limitations in chondrocyte self-renewal and conventional treatments. During cartilage regeneration and repair, growth factors are typically used to induce cartilage differentiation in stem cells. The role of thrombospondin-2 in cartilage formation has received much attention in recent years. This paper reviews the role of thrombospondin-2 in cartilage regeneration and the important role it plays in protecting cartilage from damage caused by inflammation or trauma and in the regenerative repair of cartilage by binding to different receptors and activating different intracellular signaling pathways. These studies provide new ideas for cartilage repair in clinical settings.

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