Advances in Mesenchymal Stem Cell-based Strategies for Cartilage Repair and Regeneration

Overview

Journal Stem Cell Rev Rep

Publisher Springer

Specialty Cell Biology

Date 2014 May 30

PMID 24869958

Citations 64

Authors

Wei Seong Toh

Casper Bindzus Foldager

Ming Pei

James Hoi Po Hui

Affiliations

Soon will be listed here.

Abstract

Significant research efforts have been undertaken in the last decade in the development of stem cell-based therapies for cartilage repair. Among the various stem cell sources, mesenchymal stem cells (MSCs) demonstrate great promise and clinical efficacy in cartilage regeneration. With a deeper understanding of stem cell biology, new therapeutics and new bioengineering approaches have emerged and showed potential for further developments. Of note, there has been a paradigm shift in applying MSCs for tissue regeneration from the use of stem cells for transplantation to the use of stem cell-derived matrix and secretome components as therapeutic tools and agents for cartilage regeneration. In this review, we will discuss the emerging role of MSCs in cartilage regeneration and the most recent advances in development of stem cell-based therapeutics for cartilage regeneration.

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