Respiratory Syncytial Virus-Specific Antibodies and Atopic Diseases in Children: A 10-Year Follow-Up

Overview

Journal Pathogens

Date 2023 Apr 28

PMID 37111432

Authors

Helena Tesari Crnkovic

Kreso Bendelja

Vlado Drkulec

Romana Gjergja Juraski

Mirjana Turkalj

Affiliations

Soon will be listed here.

Abstract

Background: Respiratory syncytial virus (RSV) stimulates the production of specific immunoglobulin (Ig) E and IgG4 antibodies as a hallmark of the Th2 immune response. In this paper, we evaluated the occurrence of atopic diseases in 10-year-old children who were positive for RSV-specific IgG antibodies during infancy.

Methods: The prospective follow-up of 72 children included a physical examination, an International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire and the determination of RSV-specific antibodies and total and allergen-specific IgE.

Results: Children with asthma had their first wheezing episode at a younger age (χ2 8.097, df = 1, = 0.004). RSV-specific IgG4 levels at year one were positively correlated with atopic dermatitis (AD) (tau_b = 0.211, = 0.049) and current AD (tau_b = 0.269, = 0.012); and RSV-specific IgE levels were positively correlated with allergic rhinitis (AR) (tau_b = 0.290, = 0.012) and current AR (tau_b = 0.260, = 0.025). Positive RSV-specific IgE at the age of one increased the chances of asthma occurrence by 5.94 (OR = 5.94, 95% CI = 1.05-33.64; = 0.044) and the chances of AR by more than 15 times (OR = 15.03, 95% CI = 2.08-108.72; = 0.007). A positive family history of atopy increased the chances of asthma occurrence by 5.49 times (OR = 5.49, 95% CI = 1.01-30.07; = 0.049), and a longer duration of exclusive breastfeeding lowered that chance (OR = 0.63, 95% CI = 0.45-0.89; = 0.008). Prenatal smoking increased the chances of AR occurrence by 7.63 times (OR = 7.63, 95% CI = 1.59-36.53; = 0.011).

Conclusion: RSV-specific IgE and RSV-specific IgG4 antibodies could be risk markers for the development of atopic diseases in children.

Citing Articles

The Changing Landscape of Respiratory Syncytial Virus Infections.

Bem R, van Woensel J Pathogens. 2023; 12(10).

PMID: 37887712 PMC: 10610418. DOI: 10.3390/pathogens12101196.

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