Anti-Neuroinflammatory and Neuroprotective Effect of Intermedin B Isolated from the L. Via NF-κB and ROS Inhibition in BV2 Microglia and HT22 Hippocampal Cells

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2023 Apr 28

PMID 37108568

Authors

Hwan Lee

Zhiming Liu

Linsha Dong

Dae Young Lee

Dahye Yoon

Hyuncheol Oh

Youn-Chul Kim

Ren-Bo An

Dong-Sung Lee

Affiliations

Soon will be listed here.

Abstract

Compounds derived from L. () have been extensively studied and reported to be effective and safe for the prevention and treatment of various diseases, but most research has been focused on curcuminoids derived from . As neurodegenerative diseases are associated with oxidation and inflammation, the present study aimed to isolate and identify active compounds other than curcuminoids from to develop substances to treat these diseases. Seventeen known compounds, including curcuminoids, were chromatographically isolated from the methanol extracts of , and their chemical structures were identified using 1D and 2D NMR spectroscopy. Among the isolated compounds, intermedin B exhibited the best antioxidant effect in the hippocampus and anti-inflammatory effect in microglia. Furthermore, intermedin B was confirmed to inhibit the nuclear translocation of NF-κB p-65 and IκBα, exerting anti-inflammatory effects and inhibiting the generation of reactive oxygen species, exerting neuroprotective effects. These results highlight the research value of active components other than curcuminoids in -derived compounds and suggest that intermedin B may be a promising candidate for the prevention of neurodegenerative diseases.

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