Pseudo-outbreak of at a General Hospital in Japan

Overview

Journal Infect Control Hosp Epidemiol

Publisher Cambridge University Press

Specialties Health Services
Infectious Diseases
Nursing
Public Health

Date 2023 Apr 25

PMID 37096433

Authors

Yutaro Nagano

Koji Kuronuma

Yasuo Kitamura

Kanami Nagano

Hayato Yabe

Sayaka Kudo

Toyotaka Sato

Shinya Nirasawa

Mami Nakae

Motohiro Horiuchi

Shin-Ichi Yokota

Yoshihiro Fujiya

Atsushi Saito

Satoshi Takahashi

Hirofumi Chiba

Affiliations

Soon will be listed here.

Abstract

Background: is a slow-growing nontuberculous mycobacterium that is widely distributed in soil and water systems, but it is sometimes pathogenic to humans. Although cases of infections are rare, 22 isolates of were identified at a single hospital in Japan. We suspected a nosocomial outbreak; thus, we conducted transmission pattern and genotype analyses.

Methods: Cases of isolated at Kushiro City General Hospital in Japan between May 2020 and April 2021 were analyzed. The patient samples and environmental culture specimens underwent whole-genome sequencing (WGS). Additionally, we retrospectively collected clinical data from patient medical records.

Results: Altogether, 22 isolates of were identified from sputum and bronchoalveolar lavage samples. Clinically, the instances with isolates were considered contaminants. In the WGS analysis, 19 specimens, including 18 patient samples and 1 environmental culture from the hospital's faucet, showed genetic similarity. The frequency of isolation decreased after we prohibited the use of taps where was isolated.

Conclusions: WGS analysis identified that the cause of pseudo-outbreak was the water used for patient examinations, including bronchoscopy.

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