Thromboembolism Early After Glucocorticoid Administration in Patients with Autoimmune Hemolytic Anemia

Overview

Journal Clin Hematol Int

Specialty Hematology

Date 2023 Apr 24

PMID 37093552

Authors

Kohei Shiroshita

Mikio Okayama

Hiroki Soma

Yuki Sato

Hiroyoshi Hayashi

Yuka Shiozawa

Shinichiro Okamoto

Ken Sadahira

Affiliations

Soon will be listed here.

Abstract

Pulmonary embolism and deep venous thrombosis (PE/DVT) are well-known lethal complications in autoimmune hemolytic anemia (AIHA). However, the impact of their treatment is unclear. Here, we describe three elderly Japanese patients with AIHA who developed PE/DVT early after glucocorticoid administration. All patients presented with active hemolysis and high D-dimer levels upon admission. Thromboembolism was confirmed within 2 weeks after starting glucocorticoid, suggesting that both active hemolysis and glucocorticoid administration synergistically contributed to the development of PE/DVT. Clinicians should consider that such synergism may increase the risk of thromboembolism in patients with AIHA, and prophylactic anticoagulation is worth considering in patients after starting glucocorticoid.

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