Acute COPD Exacerbation Treatment with Noninvasive Ventilation

Overview

Journal Sci Rep

Specialty Science

Date 2023 Apr 21

PMID 37085585

Authors

Ewert Ralf

Alexander Heine

Anne Obst

Karoline Koerner

Veit Hustig-Kittler

Michael Boesche

Mohamed Elhadad

Beate Stubbe

Michael Westhoff

Affiliations

Soon will be listed here.

Abstract

The establishment of a guideline for long-term noninvasive ventilation treatment (LTH-NIV) of acute hypercapnic exacerbations of chronic obstructive pulmonary disease (AECOPD) requiring acute ventilation has proven elusive. Most studies thus far have shown no mortality benefit of long-term noninvasive ventilation treatment. Using retrospective analysis of the data of our patients (n = 143) recruited from 2012 to 2019, we aimed to compare patients discharged with and without long-term noninvasive ventilation. The follow-up results showed no significant difference (p = 0.233) between the groups [LTH-NIV (n = 83); non-NIV (n = 60)] regarding readmission due to clinical worsening. However, the first- and second-year survival rates were 82% and 72%, respectively, in the LTH-NIV group and significantly different (p = 0.023) from 67 and 55% in the non-NIV group. The statistical models showed a significant mortality risk for the non-NIV group, with a hazard ratio (HR) of 2.82 (1.31; 6.03). To the best of our knowledge, this is the first study to demonstrate the mortality benefit of long-term NIV therapy for patients with AECOPD under real-world conditions.

Citing Articles

Role of Non-invasive Ventilation (NIV) in Managing Acute Exacerbations of Chronic Obstructive Pulmonary Disease (COPD): A Systematic Review.

Abualhamael S, Alasmi A, Alqurayqiri A, Alzahrani A, Alsehli A, Althikra A Cureus. 2024; 16(8):e67418.

PMID: 39310475 PMC: 11415004. DOI: 10.7759/cureus.67418.

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