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Regulation and Functions of Membrane Lipids: Insights from

Overview
Journal BBA Adv
Specialty Biochemistry
Date 2023 Apr 21
PMID 37082601
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Abstract

The plasma membrane is composed of glycerophospholipids and sphingolipids with a small cholesterol. The obtain the majority of the membrane lipids by modifying fatty acids present in the bacterial diet. The metabolic pathways of membrane lipid biosynthesis are well conserved across the animal kingdom. In CDP-DAG and Kennedy pathway produce glycerophospholipids. Meanwhile, the sphingolipids are synthesized through a different pathway. They have evolved remarkably diverse mechanisms to maintain membrane lipid homeostasis. For instance, the lipid bilayer stress operates to accomplish homeostasis during any perturbance in the lipid composition. Meanwhile, the PAQR-2/IGLR-2 complex works with FLD-1 to balance unsaturated to saturated fatty acids to maintain membrane fluidity. The loss of membrane lipid homeostasis is observed in many human genetic and metabolic disorders. Since conserved such genes and pathways, it can be used as a model organism.

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