Supplementation of Hyaluronic Acid Injections with Vitamin D Improve Knee Function by Attenuating Synovial Fluid Oxidative Stress in Osteoarthritis Patients with Vitamin D Insufficiency

Overview

Journal Front Nutr

Specialty Nutritional Sciences

Date 2023 Apr 21

PMID 37081922

Authors

Jianlin Shen

Xiaoning Lin

Yujin Lin

Jiecheng Xiao

Changfu Wu

Feng Zheng

Xianwei Wu

Haibin Lin

Guoli Chen

Huan Liu

Affiliations

Soon will be listed here.

Abstract

Objectives: There is still controversy about the effect of vitamin D supplementation on osteoarthritis (OA). The purpose of this study was to investigate the effects of vitamin D supplementation with Hyaluronic acid (HA) injection on OA.

Methods: We investigated serum vitamin D levels and oxidative stress (OS) in synovial fluid from patients with OA who underwent total knee arthroplasty (grade IV, = 24) and HA injection (grade II and III, = 40). The effects of HA injection with or without oral vitamin D supplementation on synovial fluid OS and knee pain and function were then further investigated. Finally, patients underwent HA injection were divided into two groups according to vitamin D levels (vitamin D < or > 30 ng/ml), and the efficacy of the two groups were compared.

Results: The results showed that the levels of glutathione peroxidase (GSH-PX) ( < 0.05) in the synovial fluid were lower in patients with stage IV OA than that in patients with stage II-III OA, while the levels of malondialdehyde (MDA) ( < 0.05) and lactate dehydrogenase (LDH) ( < 0.01) were significantly higher. Moreover, we found that age, BMI and vitamin D levels were significantly associated with the levels of oxidants and/or antioxidants in synovial fluid, and that vitamin D was significantly negatively correlated with BMI ( = -0.3527, = 0.0043). Supplementation of HA injections with vitamin D significantly reduced the OS status in synovial fluid, attenuated knee pain and improved knee function in OA patients with vitamin D insufficiency.

Conclusion: We conclude that maintenance of vitamin D sufficiency may be beneficial for the treatment of OA by improving OS in synovial fluid.

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