Hippocampal Sharp Wave Ripples Underlie Stress Susceptibility in Male Mice

Overview

Journal Nat Commun

Specialty Biology

Date 2023 Apr 20

PMID 37080967

Authors

Nahoko Kuga

Ryota Nakayama

Shota Morikawa

Haruya Yagishita

Daichi Konno

Hiromi Shiozaki

Natsumi Honjoya

Yuji Ikegaya

Takuya Sasaki

Affiliations

Soon will be listed here.

Abstract

The ventral hippocampus (vHC) is a core brain region for emotional memory. Here, we examined how the vHC regulates stress susceptibility from the level of gene expression to neuronal population dynamics in male mice. Transcriptome analysis of samples from stress-naïve mice revealed that intrinsic calbindin (Calb1) expression in the vHC is associated with susceptibility to social defeat stress. Mice with Calb1 gene knockdown in the vHC exhibited increased stress resilience and failed to show the increase in the poststress ventral hippocampal sharp wave ripple (SWR) rate. Poststress vHC SWRs triggered synchronous reactivation of stress memory-encoding neuronal ensembles and facilitated information transfer to the amygdala. Suppression of poststress vHC SWRs by real-time feedback stimulation or walking prevented social behavior deficits. Taken together, our results demonstrate that internal reactivation of memories of negative stressful episodes supported by ventral hippocampal SWRs serves as a crucial neurophysiological substrate for determining stress susceptibility.

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