Neural Substrates of Increased Memory Sensitivity for Negative Stimuli in Major Depression

Overview

Journal Biol Psychiatry

Publisher Elsevier

Specialty Psychiatry

Date 2008 Feb 19

PMID 18281017

Citations 152

Authors

J Paul Hamilton

Ian H Gotlib

Affiliations

Soon will be listed here.

Abstract

Background: Although memory biases for negatively valenced stimuli have been reliably associated with depression and have been postulated to play a critical role in the maintenance of this disorder, the neural bases of these biases have received little attention. In this study, we tested a model of heightened memory sensitivity for negative information in depression in which neural mechanisms that normally facilitate memory for affective material are over-recruited during encoding of negative material in depression.

Methods: We used functional magnetic resonance imaging to examine amygdala activity and functional connectivity with the hippocampus and caudate-putamen during successful encoding--as assessed by a recognition memory probe 1 week after scanning--of negative, neutral, and positive pictures by 14 depressed and 12 nondepressed individuals.

Results: Depressed individuals demonstrated greater memory sensitivity than nondepressed participants to negative but not to neutral or positive stimuli. The right amygdala was more active and showed greater functional connectivity with the hippocampus and caudate-putamen in depressed than in control participants during encoding of subsequently remembered negative but not neutral or positive stimuli. The degree of memory-related right amygdala responsivity in the depressed participants was significantly correlated with depressive severity.

Conclusions: These findings support the formulation that, in remembering negative information better than nondepressed persons, depressed individuals over-recruit a neural network involved more generally in enhancing memory for affective stimuli and that the degree to which they over-recruit this system is related to the severity of clinical symptomatology.

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References

Surguladze S, Brammer M, Keedwell P, Giampietro V, Young A, Travis M . A differential pattern of neural response toward sad versus happy facial expressions in major depressive disorder. Biol Psychiatry. 2005; 57(3):201-9. DOI: 10.1016/j.biopsych.2004.10.028. View

Siegle G, Steinhauer S, Thase M, Stenger V, Carter C . Can't shake that feeling: event-related fMRI assessment of sustained amygdala activity in response to emotional information in depressed individuals. Biol Psychiatry. 2002; 51(9):693-707. DOI: 10.1016/s0006-3223(02)01314-8. View

Canli T, Zhao Z, Brewer J, Gabrieli J, Cahill L . Event-related activation in the human amygdala associates with later memory for individual emotional experience. J Neurosci. 2000; 20(19):RC99. PMC: 6772800. View

Sheline Y, Barch D, Donnelly J, Ollinger J, Snyder A, Mintun M . Increased amygdala response to masked emotional faces in depressed subjects resolves with antidepressant treatment: an fMRI study. Biol Psychiatry. 2001; 50(9):651-8. DOI: 10.1016/s0006-3223(01)01263-x. View

Levy R, Friedman H, Davachi L, Goldman-Rakic P . Differential activation of the caudate nucleus in primates performing spatial and nonspatial working memory tasks. J Neurosci. 1997; 17(10):3870-82. PMC: 6573717. View

Watkins P, Mathews A, Williamson D, Fuller R . Mood-congruent memory in depression: emotional priming or elaboration?. J Abnorm Psychol. 1992; 101(3):581-6. DOI: 10.1037//0021-843x.101.3.581. View

Zimmerman D . Statistical significance levels of nonparametric tests biased by heterogeneous variances of treatment groups. J Gen Psychol. 2000; 127(4):354-64. DOI: 10.1080/00221300009598589. View

Fu C, Williams S, Cleare A, Brammer M, Walsh N, Kim J . Attenuation of the neural response to sad faces in major depression by antidepressant treatment: a prospective, event-related functional magnetic resonance imaging study. Arch Gen Psychiatry. 2004; 61(9):877-89. DOI: 10.1001/archpsyc.61.9.877. View

Ridout N, Astell A, Reid I, Glen T, OCarroll R . Memory bias for emotional facial expressions in major depression. Cogn Emot. 2018; 17(1):101-122. DOI: 10.1080/02699930302272. View

10.

Adolphs R, Cahill L, Schul R, Babinsky R . Impaired declarative memory for emotional material following bilateral amygdala damage in humans. Learn Mem. 1999; 4(3):291-300. DOI: 10.1101/lm.4.3.291. View

11.

Dolcos F, LaBar K, Cabeza R . Interaction between the amygdala and the medial temporal lobe memory system predicts better memory for emotional events. Neuron. 2004; 42(5):855-63. DOI: 10.1016/s0896-6273(04)00289-2. View

12.

Roberson-Nay R, McClure E, Monk C, Nelson E, Guyer A, Fromm S . Increased amygdala activity during successful memory encoding in adolescent major depressive disorder: An FMRI study. Biol Psychiatry. 2006; 60(9):966-73. DOI: 10.1016/j.biopsych.2006.02.018. View

13.

Atallah H, Lopez-Paniagua D, Rudy J, OReilly R . Separate neural substrates for skill learning and performance in the ventral and dorsal striatum. Nat Neurosci. 2006; 10(1):126-31. DOI: 10.1038/nn1817. View

14.

Posse S, Fitzgerald D, Gao K, Habel U, Rosenberg D, Moore G . Real-time fMRI of temporolimbic regions detects amygdala activation during single-trial self-induced sadness. Neuroimage. 2003; 18(3):760-8. DOI: 10.1016/s1053-8119(03)00004-1. View

15.

Steinvorth S, Levine B, Corkin S . Medial temporal lobe structures are needed to re-experience remote autobiographical memories: evidence from H.M. and W.R. Neuropsychologia. 2005; 43(4):479-96. DOI: 10.1016/j.neuropsychologia.2005.01.001. View

16.

Bradley B, Mogg K, Williams R . Implicit and explicit memory for emotion-congruent information in clinical depression and anxiety. Behav Res Ther. 1995; 33(7):755-70. DOI: 10.1016/0005-7967(95)00029-w. View

17.

Glover G, Law C . Spiral-in/out BOLD fMRI for increased SNR and reduced susceptibility artifacts. Magn Reson Med. 2001; 46(3):515-22. DOI: 10.1002/mrm.1222. View

18.

Kensinger E, Corkin S . Two routes to emotional memory: distinct neural processes for valence and arousal. Proc Natl Acad Sci U S A. 2004; 101(9):3310-5. PMC: 365786. DOI: 10.1073/pnas.0306408101. View

19.

Burt D, Zembar M, Niederehe G . Depression and memory impairment: a meta-analysis of the association, its pattern, and specificity. Psychol Bull. 1995; 117(2):285-305. DOI: 10.1037/0033-2909.117.2.285. View

20.

Heekeren H, Marrett S, Bandettini P, Ungerleider L . A general mechanism for perceptual decision-making in the human brain. Nature. 2004; 431(7010):859-62. DOI: 10.1038/nature02966. View