Behavioral and Emotional Difficulties and HIV Treatment Outcomes Among HIV-infected Children in Rural Southwestern China

Overview

Journal Child Adolesc Psychiatry Ment Health

Publisher Biomed Central

Date 2023 Apr 19

PMID 37072804

Authors

Yesheng Zhou

Kailing Tang

Hongyan Lu

Hongli Chen

Haomin Xie

Zeyu Li

Jinghua Huang

Ningye Fang

Siya Chen

Hong Wang

Qin He

Huanhuan Chen

Xiu Liu

Guanghua Lan

Qiuying Zhu

Yi Chen

Xiangjun Zhang

Yuhua Ruan

Shujia Liang

Affiliations

Soon will be listed here.

Abstract

Background: Previous studies have not clearly demonstrated the impact of behavioral and emotional problems (BEDs) on treatment outcomes among HIV-infected children on antiretroviral therapy (ART). This study aimed to describe the prevalence of BEDs among this population and identify the factors associated with HIV treatment outcomes.

Methods: This cross-sectional study was conducted in Guangxi, China, between July and August 2021. HIV-infected children answered questionnaires about BEDs, physical health, social support, and whether they have missed doses in the past month. BEDs were assessed using the Chinese version of the self-reported Strengths and Difficulties Questionnaire (SDQ-C). The self-reported survey data were linked to participants' HIV care information that was obtained from the national surveillance database. Univariate and multivariate logistic regression models were used to identify factors that were associated with missed doses in the past month and virological failure.

Results: The study sample was 325 HIV-infected children. HIV-infected children had a higher proportion of abnormal scores on SDQ-C total difficulties compared to their peers in the general population (16.9 vs 10.0%; P = 0.002). An abnormal SDQ-C total difficulties score (AOR = 2.06, 95%CI: 1.10-3.88) and infrequency of receiving assistance and support from parents over the past 3 months (AOR = 1.85, 95%CI: 1.12-3.06) were significantly associated with missed doses in the past month. Between the ages of 14-17 years (AOR = 2.66, 95% CI: 1.37-5.16), female (AOR = 2.21, 95% CI: 1.20-4.08), and suboptimal adherence (AOR = 2.45, 95% CI: 1.32-4.57) were significantly associated with virological failure.

Conclusions: Children's mental health plays a role in HIV treatment outcomes. Psychological interventions should be promoted in pediatric HIV care clinics to improve children's mental health status and HIV treatment outcomes.

Citing Articles

Prevalence of mental disorders among young people living with HIV: a systematic review and meta-analysis.

Zhan S, Ouyang F, Zhai W, Yang H Front Public Health. 2024; 12:1392872.

PMID: 39234077 PMC: 11372585. DOI: 10.3389/fpubh.2024.1392872.

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