METTL3-Mediated M6A Modification Controls Splicing Factor Abundance and Contributes to Aggressive CLL

Overview

Journal Blood Cancer Discov

Specialties Hematology
Oncology

Date 2023 Apr 17

PMID 37067905

Authors

Yiming Wu

Meiling Jin

Mike Fernandez

Kevyn L Hart

Aijun Liao

Xinzhou Ge

Stacey M Fernandes

Tinisha McDonald

Zhenhua Chen

Daniel Roth

Lucy Y Ghoda

Guido Marcucci

Markus Kalkum

Raju K Pillai

Alexey V Danilov

Jingyi Jessica Li

Jianjun Chen

Jennifer R Brown

Steven T Rosen

Tanya Siddiqi

Lili Wang

Affiliations

Soon will be listed here.

Abstract

Significance: METTL3 controls widespread splicing factor abundance via translational control of m6A-modified mRNA, contributes to RNA splicing dysregulation and disease progression in CLL, and serves as a potential therapeutic target in aggressive CLL. See related commentary by Janin and Esteller, p. 176. This article is highlighted in the In This Issue feature, p. 171.

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