Non-pituitary GH Regulation of the Tissue Microenvironment

Overview

Journal Endocr Relat Cancer

Specialties Endocrinology
Oncology

Date 2023 Apr 17

PMID 37066857

Authors

Vera Chesnokova

Shlomo Melmed

Affiliations

Soon will be listed here.

Abstract

Non-pituitary growth hormone (npGH) expression is well established in extrapituitary tissues, but an understanding of the physiological role of npGH remains rather limited. Pro-tumorigenic npGH impacting the tumor microenvironment has been reviewed. We focus here on autocrine/paracrine npGH effects in non-tumorous tissues and discuss its mechanisms of action in the normal tissue microenvironment. We address the tissue-specific effects of npGH in regulating stem, endothelial, immune, and epithelial cells and highlight the related role of npGH-associated changes in tissue aging.

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