Recent Developments and Trends in Asymmetric Organocatalysis

Overview

Journal European J Org Chem

Specialty Biochemistry

Date 2023 Apr 17

PMID 37065706

Authors

Olga Garcia Mancheno

Mario Waser

Affiliations

Soon will be listed here.

Abstract

Asymmetric organocatalysis has experienced a long and spectacular way since the early reports over a century ago by von Liebig, Knoevenagel and Bredig, showing that small (chiral) organic molecules can catalyze (asymmetric) reactions. This was followed by impressive first highly enantioselective reports in the second half of the last century, until the hype initiated in 2000 by the milestone publications of MacMillan and List, which finally culminated in the 2021 Nobel Prize in Chemistry. This short Perspective aims at providing a brief introduction to the field by first looking on the historical development and the more classical methods and concepts, followed by discussing selected advanced recent examples that opened new directions and diversity within this still growing field.

Citing Articles

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Noncanonical Amino Acids: Bringing New-to-Nature Functionalities to Biocatalysis.

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