The First 3D-bioprinted Personalized Active Bone to Repair Bone Defects: A Case Report

Overview

Journal Int J Bioprint

Specialty Biomedical Engineering

Date 2023 Apr 17

PMID 37065664

Authors

Yongqiang Hao

Bojun Cao

Liang Deng

Jiaxin Li

Zhaoyang Ran

Junxiang Wu

Boran Pang

Jia Tan

Dinghao Luo

Wen Wu

Affiliations

Soon will be listed here.

Abstract

The repair and reconstruction of bone defects are still major problems to be solved in the field of orthopedics. Meanwhile, 3D-bioprinted active bone implants may provide a new and effective solution. In this case, we used bioink prepared from the patient's autologous platelet-rich plasma (PRP) combined with polycaprolactone/β-tricalcium phosphate (PCL/β-TCP) composite scaffold material to print personalized PCL/β-TCP/PRP active scaffolds layer by layer through 3D bioprinting technology. The scaffold was then applied in the patient to repair and reconstruct bone defect after tibial tumor resection. Compared with traditional bone implant materials, 3D-bioprinted personalized active bone will have significant clinical application prospects due to its advantages of biological activity, osteoinductivity, and personalized design.

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