Ferroptosis Landscape in Prostate Cancer from Molecular and Metabolic Perspective

Overview

Journal Cell Death Discov

Date 2023 Apr 15

PMID 37061523

Authors

Jiaming Liang

Yihao Liao

Pu Wang

Kun Yang

Youzhi Wang

Keke Wang

Boqiang Zhong

Diansheng Zhou

Qian Cao

Junbo Li

Yang Zhao

Ning Jiang

Affiliations

Soon will be listed here.

Abstract

Prostate cancer is a major disease that threatens men's health. Its rapid progression, easy metastasis, and late castration resistance have brought obstacles to treatment. It is necessary to find new effective anticancer methods. Ferroptosis is a novel iron-dependent programmed cell death that plays a role in various cancers. Understanding how ferroptosis is regulated in prostate cancer will help us to use it as a new way to kill cancer cells. In this review, we summarize the regulation and role of ferroptosis in prostate cancer and the relationship with AR from the perspective of metabolism and molecular pathways. We also discuss the feasibility of ferroptosis in prostate cancer treatment and describe current limitations and prospects, providing a reference for future research and clinical application of ferroptosis.

Citing Articles

HMGA2 regulates GPX4 expression and ferroptosis in prostate cancer cells.

Dike P, Hwang B, Campbell T, Awolowo M, Elliott B, Odero-Marah V Biochem Biophys Res Commun. 2024; 736:150859.

PMID: 39447278 PMC: 11560499. DOI: 10.1016/j.bbrc.2024.150859.

TRIM47 promotes the Warburg effect and reduces ferroptosis in prostate cancer by FBP1 and FOXO1.

Zhao C, Liu Z, Peng J, Huang J, Guo J Transl Androl Urol. 2024; 13(9):1991-2004.

PMID: 39434735 PMC: 11491198. DOI: 10.21037/tau-23-605.

Mechanisms of ferroptosis and targeted therapeutic approaches in urological malignancies.

Ma W, Jiang X, Jia R, Li Y Cell Death Discov. 2024; 10(1):432.

PMID: 39384767 PMC: 11464522. DOI: 10.1038/s41420-024-02195-w.

Icariin‑curcumol promotes ferroptosis in prostate cancer cells through Nrf2/HO‑1 signaling.

Sheng W, Li B, Sun T, Zhu C, Li Y, Xu W Exp Ther Med. 2024; 27(5):232.

PMID: 38628654 PMC: 11019657. DOI: 10.3892/etm.2024.12519.

YAP1 Regulates the YAP1/AR/PSA Axis through Autophagy in Castration-Resistant Prostate Cancer and Mediates T-Cell Immune and Inflammatory Cytokine Infiltration.

Wang Y, Wu N, Li J, Zhou D, Liang J, Cao Q Biomedicines. 2024; 12(3).

PMID: 38540274 PMC: 10967749. DOI: 10.3390/biomedicines12030661.

References

Bramhecha Y, Guerard K, Audet-Walsh E, Rouzbeh S, Kassem O, Pernet E . Fatty acid oxidation enzyme Δ3, Δ2-enoyl-CoA isomerase 1 (ECI1) drives aggressive tumor phenotype and predicts poor clinical outcome in prostate cancer patients. Oncogene. 2022; 41(20):2798-2810. DOI: 10.1038/s41388-022-02276-z. View

Keer H, Kozlowski J, Tsai Y, Lee C, McEwan R, Grayhack J . Elevated transferrin receptor content in human prostate cancer cell lines assessed in vitro and in vivo. J Urol. 1990; 143(2):381-5. DOI: 10.1016/s0022-5347(17)39970-6. View

Torti S, Torti F . Iron and Cancer: 2020 Vision. Cancer Res. 2020; 80(24):5435-5448. PMC: 8118237. DOI: 10.1158/0008-5472.CAN-20-2017. View

Feder J, Penny D, Irrinki A, Lee V, Lebron J, Watson N . The hemochromatosis gene product complexes with the transferrin receptor and lowers its affinity for ligand binding. Proc Natl Acad Sci U S A. 1998; 95(4):1472-7. PMC: 19050. DOI: 10.1073/pnas.95.4.1472. View

Uo T, Sprenger C, Plymate S . Androgen Receptor Signaling and Metabolic and Cellular Plasticity During Progression to Castration Resistant Prostate Cancer. Front Oncol. 2020; 10:580617. PMC: 7581990. DOI: 10.3389/fonc.2020.580617. View

Balogh E, Paragh G, Jeney V . Influence of Iron on Bone Homeostasis. Pharmaceuticals (Basel). 2018; 11(4). PMC: 6316285. DOI: 10.3390/ph11040107. View

Nakamura E, Sato M, Yang H, Miyagawa F, Harasaki M, Tomita K . 4F2 (CD98) heavy chain is associated covalently with an amino acid transporter and controls intracellular trafficking and membrane topology of 4F2 heterodimer. J Biol Chem. 1999; 274(5):3009-16. DOI: 10.1074/jbc.274.5.3009. View

Koppula P, Zhang Y, Zhuang L, Gan B . Amino acid transporter SLC7A11/xCT at the crossroads of regulating redox homeostasis and nutrient dependency of cancer. Cancer Commun (Lond). 2018; 38(1):12. PMC: 5993148. DOI: 10.1186/s40880-018-0288-x. View

Peet N, Grabowski P, Skerry T . The glutamate receptor antagonist MK801 modulates bone resorption in vitro by a mechanism predominantly involving osteoclast differentiation. FASEB J. 1999; 13(15):2179-85. DOI: 10.1096/fasebj.13.15.2179. View

10.

Ebersbach C, Beier A, Thomas C, Erb H . Impact of STAT Proteins in Tumor Progress and Therapy Resistance in Advanced and Metastasized Prostate Cancer. Cancers (Basel). 2021; 13(19). PMC: 8508518. DOI: 10.3390/cancers13194854. View

11.

Yoshizawa K, Willett W, Morris S, Stampfer M, Spiegelman D, Rimm E . Study of prediagnostic selenium level in toenails and the risk of advanced prostate cancer. J Natl Cancer Inst. 1998; 90(16):1219-24. DOI: 10.1093/jnci/90.16.1219. View

12.

Kong Z, Liu R, Cheng Y . Artesunate alleviates liver fibrosis by regulating ferroptosis signaling pathway. Biomed Pharmacother. 2018; 109:2043-2053. DOI: 10.1016/j.biopha.2018.11.030. View

13.

Ingold I, Berndt C, Schmitt S, Doll S, Poschmann G, Buday K . Selenium Utilization by GPX4 Is Required to Prevent Hydroperoxide-Induced Ferroptosis. Cell. 2018; 172(3):409-422.e21. DOI: 10.1016/j.cell.2017.11.048. View

14.

Wang Z, Li M, Liu Y, Qiao Z, Bai T, Yang L . Dihydroartemisinin triggers ferroptosis in primary liver cancer cells by promoting and unfolded protein response‑induced upregulation of CHAC1 expression. Oncol Rep. 2021; 46(5). PMC: 8485000. DOI: 10.3892/or.2021.8191. View

15.

Chen J, Wang Y, Han L, Wang R, Gong C, Yang G . A ferroptosis-inducing biomimetic nanocomposite for the treatment of drug-resistant prostate cancer. Mater Today Bio. 2022; 17:100484. PMC: 9649379. DOI: 10.1016/j.mtbio.2022.100484. View

16.

Ye L, Jin F, Kumar S, Dai Y . The mechanisms and therapeutic targets of ferroptosis in cancer. Expert Opin Ther Targets. 2021; 25(11):965-986. DOI: 10.1080/14728222.2021.2011206. View

17.

Clark L, Combs Jr G, Turnbull B, Slate E, Chalker D, Chow J . Effects of selenium supplementation for cancer prevention in patients with carcinoma of the skin. A randomized controlled trial. Nutritional Prevention of Cancer Study Group. JAMA. 1996; 276(24):1957-63. View

18.

Suzuki Y, Kondo Y, Himeno S, Nemoto K, Akimoto M, Imura N . Role of antioxidant systems in human androgen-independent prostate cancer cells. Prostate. 2001; 43(2):144-9. DOI: 10.1002/(sici)1097-0045(20000501)43:2<144::aid-pros9>3.0.co;2-h. View

19.

Martinez E, Darke A, Tangen C, Goodman P, Fowke J, Klein E . A functional variant in NKX3.1 associated with prostate cancer risk in the Selenium and Vitamin E Cancer Prevention Trial (SELECT). Cancer Prev Res (Phila). 2014; 7(9):950-7. PMC: 4154984. DOI: 10.1158/1940-6207.CAPR-14-0075. View

20.

Forcina G, Pope L, Murray M, Dong W, Abu-Remaileh M, Bertozzi C . Ferroptosis regulation by the NGLY1/NFE2L1 pathway. Proc Natl Acad Sci U S A. 2022; 119(11):e2118646119. PMC: 8931371. DOI: 10.1073/pnas.2118646119. View