Influence of Iron on Bone Homeostasis

Overview

Journal Pharmaceuticals (Basel)

Publisher MDPI

Specialty Chemistry

Date 2018 Oct 21

PMID 30340370

Citations 65

Authors

Eniko Balogh

Gyorgy Paragh

Viktoria Jeney

Affiliations

Soon will be listed here.

Abstract

Bone homeostasis is a complex process, wherein osteoclasts resorb bone and osteoblasts produce new bone tissue. For the maintenance of skeletal integrity, this sequence has to be tightly regulated and orchestrated. Iron overload as well as iron deficiency disrupt the delicate balance between bone destruction and production, via influencing osteoclast and osteoblast differentiation as well as activity. Iron overload as well as iron deficiency are accompanied by weakened bones, suggesting that balanced bone homeostasis requires optimal-not too low, not too high-iron levels. The goal of this review is to summarize our current knowledge about how imbalanced iron influence skeletal health. Better understanding of this complex process may help the development of novel therapeutic approaches to deal with the pathologic effects of altered iron levels on bone.

Citing Articles

Osteosarcoma Cells and Undifferentiated Human Mesenchymal Stromal Cells Are More Susceptible to Ferroptosis than Differentiated Human Mesenchymal Stromal Cells.

Smirnova Y, Hanetseder D, Derigo L, Gasser A, Vaglio-Garro A, Sperger S Antioxidants (Basel). 2025; 14(2).

PMID: 40002376 PMC: 11852062. DOI: 10.3390/antiox14020189.

Iron metabolism in rheumatic diseases.

Givian A, Azizan A, Jamshidi A, Mahmoudi M, Farhadi E J Transl Autoimmun. 2025; 10:100267.

PMID: 39867458 PMC: 11763848. DOI: 10.1016/j.jtauto.2025.100267.

Does the Nutrient Adequacy Ratio (NAR) Predict Metabolic Profile and Glycemic Status Among the Obese Population?.

Sarghein M, Farhangi M, Nikrad N Nutr Metab Insights. 2025; 18:11786388241309847.

PMID: 39758454 PMC: 11694301. DOI: 10.1177/11786388241309847.

Levels of substitution of inorganic mineral to amino acids complexed minerals on old laying hens.

Santos M, Rabello C, Wanderley J, Ludke M, Barros M, Costa F Sci Rep. 2024; 14(1):24803.

PMID: 39438582 PMC: 11496821. DOI: 10.1038/s41598-024-75897-x.

Nutraceuticals in osteoporosis prevention.

Roseti L, Borciani G, Grassi F, Desando G, Gambari L, Grigolo B Front Nutr. 2024; 11:1445955.

PMID: 39416651 PMC: 11479890. DOI: 10.3389/fnut.2024.1445955.

References

Takahashi N, Udagawa N, Suda T . A new member of tumor necrosis factor ligand family, ODF/OPGL/TRANCE/RANKL, regulates osteoclast differentiation and function. Biochem Biophys Res Commun. 1999; 256(3):449-55. DOI: 10.1006/bbrc.1999.0252. View

Ruggiero L, De Sanctis V . Multicentre study on prevalence of fractures in transfusion-dependent thalassaemic patients. J Pediatr Endocrinol Metab. 1999; 11 Suppl 3:773-8. View

Semenza G . Regulation of mammalian O2 homeostasis by hypoxia-inducible factor 1. Annu Rev Cell Dev Biol. 1999; 15:551-78. DOI: 10.1146/annurev.cellbio.15.1.551. View

Camaschella C, Roetto A, Cali A, De Gobbi M, Garozzo G, Carella M . The gene TFR2 is mutated in a new type of haemochromatosis mapping to 7q22. Nat Genet. 2000; 25(1):14-5. DOI: 10.1038/75534. View

Zacharski L, Ornstein D, Woloshin S, Schwartz L . Association of age, sex, and race with body iron stores in adults: analysis of NHANES III data. Am Heart J. 2000; 140(1):98-104. DOI: 10.1067/mhj.2000.106646. View

Kato I, Dnistrian A, Schwartz M, Toniolo P, Koenig K, Shore R . Risk of iron overload among middle-aged women. Int J Vitam Nutr Res. 2000; 70(3):119-25. DOI: 10.1024/0300-9831.70.3.119. View

Kawashima A, Oda Y, Yachie A, Koizumi S, Nakanishi I . Heme oxygenase-1 deficiency: the first autopsy case. Hum Pathol. 2002; 33(1):125-30. DOI: 10.1053/hupa.2002.30217. View

Cummings S, Melton L . Epidemiology and outcomes of osteoporotic fractures. Lancet. 2002; 359(9319):1761-7. DOI: 10.1016/S0140-6736(02)08657-9. View

Fiedler J, Roderer G, Gunther K, Brenner R . BMP-2, BMP-4, and PDGF-bb stimulate chemotactic migration of primary human mesenchymal progenitor cells. J Cell Biochem. 2002; 87(3):305-12. DOI: 10.1002/jcb.10309. View

10.

Roetto A, Papanikolaou G, Politou M, Alberti F, Girelli D, Christakis J . Mutant antimicrobial peptide hepcidin is associated with severe juvenile hemochromatosis. Nat Genet. 2002; 33(1):21-2. DOI: 10.1038/ng1053. View

11.

Takayanagi H, Kim S, Koga T, Nishina H, Isshiki M, Yoshida H . Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling in terminal differentiation of osteoclasts. Dev Cell. 2002; 3(6):889-901. DOI: 10.1016/s1534-5807(02)00369-6. View

12.

Koduri P . Iron in sickle cell disease: a review why less is better. Am J Hematol. 2003; 73(1):59-63. DOI: 10.1002/ajh.10313. View

13.

Arnett T, Gibbons D, Utting J, Orriss I, Hoebertz A, Rosendaal M . Hypoxia is a major stimulator of osteoclast formation and bone resorption. J Cell Physiol. 2003; 196(1):2-8. DOI: 10.1002/jcp.10321. View

14.

Milman N, Byg K, Ovesen L, Kirchhoff M, Jurgensen K . Iron status in Danish women, 1984-1994: a cohort comparison of changes in iron stores and the prevalence of iron deficiency and iron overload. Eur J Haematol. 2003; 71(1):51-61. DOI: 10.1034/j.1600-0609.2003.00090.x. View

15.

Teitelbaum S, Ross F . Genetic regulation of osteoclast development and function. Nat Rev Genet. 2003; 4(8):638-49. DOI: 10.1038/nrg1122. View

16.

Franceschi R, Xiao G, Jiang D, Gopalakrishnan R, Yang S, Reith E . Multiple signaling pathways converge on the Cbfa1/Runx2 transcription factor to regulate osteoblast differentiation. Connect Tissue Res. 2003; 44 Suppl 1:109-16. PMC: 3564252. View

17.

Hayman A, Cox T . Tartrate-resistant acid phosphatase knockout mice. J Bone Miner Res. 2003; 18(10):1905-7. DOI: 10.1359/jbmr.2003.18.10.1905. View

18.

Papanikolaou G, Samuels M, Ludwig E, Macdonald M, Franchini P, Dube M . Mutations in HFE2 cause iron overload in chromosome 1q-linked juvenile hemochromatosis. Nat Genet. 2003; 36(1):77-82. DOI: 10.1038/ng1274. View

19.

Liu J, Hankinson S, Stampfer M, Rifai N, Willett W, Ma J . Body iron stores and their determinants in healthy postmenopausal US women. Am J Clin Nutr. 2003; 78(6):1160-7. DOI: 10.1093/ajcn/78.6.1160. View

20.

Pietrangelo A . The ferroportin disease. Blood Cells Mol Dis. 2004; 32(1):131-8. DOI: 10.1016/j.bcmd.2003.08.003. View