Alcohol and Immunology: Mechanisms of Multi-organ Damage. Summary of the 2022 Alcohol and Immunology Research Interest Group (AIRIG) Meeting

Overview

Journal Alcohol

Specialty Psychiatry

Date 2023 Apr 15

PMID 37061143

Authors

Rachel H McMahan

Paige Anton

Leon G Coleman

Gail A M Cresci

Fulton T Crews

Kathryn M Crotty

Marisa E Luck

Patricia E Molina

Vidula Vachharajani

Joanne Weinberg

Samantha M Yeligar

Mashkoor A Choudhry

Rebecca L McCullough

Elizabeth J Kovacs

Affiliations

Soon will be listed here.

Abstract

On October 26th, 2022 the annual Alcohol and Immunology Research Interest Group (AIRIG) meeting was held as a satellite symposium at the annual meeting of the Society for Leukocyte Biology in Hawaii. The 2022 meeting focused broadly on the immunological consequences of acute, chronic, and prenatal alcohol exposure and how these contribute to damage in multiple organs and tissues. These included alcohol-induced neuroinflammation, impaired lung immunity, intestinal dysfunction, and decreased anti-microbial and anti-viral responses. In addition, research presented covered multiple pathways behind alcohol-induced cellular dysfunction, including mitochondrial metabolism, cellular bioenergetics, gene regulation, and epigenetics. Finally, the work presented highlighted potential biomarkers and novel avenues of treatment for alcohol-induced organ damage.

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References

Smirnova E, Puri P, Muthiah M, Daitya K, Brown R, Chalasani N . Fecal Microbiome Distinguishes Alcohol Consumption From Alcoholic Hepatitis But Does Not Discriminate Disease Severity. Hepatology. 2020; 72(1):271-286. PMC: 7752764. DOI: 10.1002/hep.31178. View

Moss M, Burnham E . Chronic alcohol abuse, acute respiratory distress syndrome, and multiple organ dysfunction. Crit Care Med. 2003; 31(4 Suppl):S207-12. DOI: 10.1097/01.CCM.0000057845.77458.25. View

Hallgren R, Samuelsson T, Laurent T, Modig J . Accumulation of hyaluronan (hyaluronic acid) in the lung in adult respiratory distress syndrome. Am Rev Respir Dis. 1989; 139(3):682-7. DOI: 10.1164/ajrccm/139.3.682. View

Bodnar T, Raineki C, Wertelecki W, Yevtushok L, Plotka L, Zymak-Zakutnya N . Altered maternal immune networks are associated with adverse child neurodevelopment: Impact of alcohol consumption during pregnancy. Brain Behav Immun. 2018; 73:205-215. PMC: 6344127. DOI: 10.1016/j.bbi.2018.05.004. View

Bodnar T, Hill L, Weinberg J . Evidence for an immune signature of prenatal alcohol exposure in female rats. Brain Behav Immun. 2016; 58:130-141. PMC: 5067180. DOI: 10.1016/j.bbi.2016.05.022. View

Williams J, Smith V . Fetal Alcohol Spectrum Disorders. Pediatrics. 2015; 136(5):e1395-406. DOI: 10.1542/peds.2015-3113. View

Silver G, Albright J, Schermer C, Halerz M, Conrad P, Ackerman P . Adverse clinical outcomes associated with elevated blood alcohol levels at the time of burn injury. J Burn Care Res. 2008; 29(5):784-9. PMC: 2909589. DOI: 10.1097/BCR.0b013e31818481bc. View

Coleman Jr L, Zou J, Crews F . Microglial-derived miRNA let-7 and HMGB1 contribute to ethanol-induced neurotoxicity via TLR7. J Neuroinflammation. 2017; 14(1):22. PMC: 5264311. DOI: 10.1186/s12974-017-0799-4. View

Crews F, Lawrimore C, Jordan Walter T, Coleman Jr L . The role of neuroimmune signaling in alcoholism. Neuropharmacology. 2017; 122:56-73. PMC: 5493978. DOI: 10.1016/j.neuropharm.2017.01.031. View

10.

Stephenson J, Nutma E, van der Valk P, Amor S . Inflammation in CNS neurodegenerative diseases. Immunology. 2018; 154(2):204-219. PMC: 5980185. DOI: 10.1111/imm.12922. View

11.

Coleman Jr L, Crews F, Vetreno R . The persistent impact of adolescent binge alcohol on adult brain structural, cellular, and behavioral pathology: A role for the neuroimmune system and epigenetics. Int Rev Neurobiol. 2021; 160:1-44. DOI: 10.1016/bs.irn.2021.08.001. View

12.

Gandhirajan A, Roychowdhury S, Kibler C, Bauer S, Nagy L, Vachharajani V . Ethanol Exposure Attenuates Immune Response in Sepsis via Sirtuin 2 Expression. Alcohol Clin Exp Res. 2020; 45(2):338-350. PMC: 7974377. DOI: 10.1111/acer.14542. View

13.

Luck M, Li X, Herrnreiter C, Cannon A, Choudhry M . IL-27 Promotes Intestinal Barrier Integrity following Ethanol Intoxication and Burn Injury. Immunohorizons. 2022; 6(8):600-613. DOI: 10.4049/immunohorizons.2200032. View

14.

Esser M, Leung G, Sherk A, Bohm M, Liu Y, Lu H . Estimated Deaths Attributable to Excessive Alcohol Use Among US Adults Aged 20 to 64 Years, 2015 to 2019. JAMA Netw Open. 2022; 5(11):e2239485. PMC: 9627409. DOI: 10.1001/jamanetworkopen.2022.39485. View

15.

Maffei V, Ferguson T, Brashear M, Mercante D, Theall K, Siggins R . Lifetime alcohol use among persons living with HIV is associated with frailty. AIDS. 2019; 34(2):245-254. PMC: 6960033. DOI: 10.1097/QAD.0000000000002426. View

16.

Yeligar S, Mehta A, Harris F, Brown L, Hart C . Peroxisome Proliferator-Activated Receptor γ Regulates Chronic Alcohol-Induced Alveolar Macrophage Dysfunction. Am J Respir Cell Mol Biol. 2015; 55(1):35-46. PMC: 4942203. DOI: 10.1165/rcmb.2015-0077OC. View

17.

Glueck B, Han Y, Cresci G . Tributyrin Supplementation Protects Immune Responses and Vasculature and Reduces Oxidative Stress in the Proximal Colon of Mice Exposed to Chronic-Binge Ethanol Feeding. J Immunol Res. 2018; 2018:9671919. PMC: 6120279. DOI: 10.1155/2018/9671919. View

18.

Kavanaugh M, Clark C, Goto M, Kovacs E, Gamelli R, Sayeed M . Effect of acute alcohol ingestion prior to burn injury on intestinal bacterial growth and barrier function. Burns. 2005; 31(3):290-6. DOI: 10.1016/j.burns.2004.09.021. View

19.

Crews F, Coleman Jr L, Macht V, Vetreno R . Targeting Persistent Changes in Neuroimmune and Epigenetic Signaling in Adolescent Drinking to Treat Alcohol Use Disorder in Adulthood. Pharmacol Rev. 2023; 75(2):380-396. PMC: 9969522. DOI: 10.1124/pharmrev.122.000710. View

20.

OBrien Jr J, Lu B, Ali N, Martin G, Aberegg S, Marsh C . Alcohol dependence is independently associated with sepsis, septic shock, and hospital mortality among adult intensive care unit patients. Crit Care Med. 2007; 35(2):345-50. DOI: 10.1097/01.CCM.0000254340.91644.B2. View