The Biology and Type I/III Hybrid Nature of Type I-D CRISPR-Cas Systems

Overview

Journal Biochem J

Specialty Biochemistry

Date 2023 Apr 13

PMID 37052300

Authors

Tess M McBride

Shaharn C Cameron

Peter C Fineran

Robert D Fagerlund

Affiliations

Soon will be listed here.

Abstract

Prokaryotes have adaptive defence mechanisms that protect them from mobile genetic elements and viral infection. One defence mechanism is called CRISPR-Cas (clustered regularly interspaced short palindromic repeats and CRISPR-associated proteins). There are six different types of CRISPR-Cas systems and multiple subtypes that vary in composition and mode of action. Type I and III CRISPR-Cas systems utilise multi-protein complexes, which differ in structure, nucleic acid binding and cleaving preference. The type I-D system is a chimera of type I and III systems. Recently, there has been a burst of research on the type I-D CRISPR-Cas system. Here, we review the mechanism, evolution and biotechnological applications of the type I-D CRISPR-Cas system.

Citing Articles

Research Progress on the Mechanism and Application of the Type I CRISPR-Cas System.

Yang P, Zhang S, Hu D, Li X, Guo Y, Guo H Int J Mol Sci. 2024; 25(23).

PMID: 39684256 PMC: 11640852. DOI: 10.3390/ijms252312544.

Type I CRISPR-Cas-mediated microbial gene editing and regulation.

Xu Z, Chen S, Wu W, Wen Y, Cao H AIMS Microbiol. 2024; 9(4):780-800.

PMID: 38173969 PMC: 10758571. DOI: 10.3934/microbiol.2023040.

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