Selenonium Salt As a Catalyst for Nucleophilic Substitution Reactions in Water: Synthesis of Thiocyanites and Selenocyanates

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2023 Apr 13

PMID 37049818

Authors

Alix Y Bastidas Angel

Philipe Raphael O Campos

Eduardo E Alberto

Affiliations

Soon will be listed here.

Abstract

Organothiocyanates and selenocyanates are valuable compounds, both in terms of functional group interconversion and due to their biological activities. In this contribution, we report the synthesis of a series of these important substances in a mixture of water and dimethyl carbonate (20/1 proportion) using potassium thio- or selenocyanates salts and organic bromides. The key to the effectiveness of the reaction is a chalcogen bond interaction between a selenonium salt catalyst and the organic substrate.

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PMID: 39233358 PMC: 11421007. DOI: 10.1021/acs.joc.4c00997.

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