A Meta-Analysis of the Prevalence of Wheat Allergy Worldwide

Overview

Journal Nutrients

Date 2023 Apr 13

PMID 37049405

Authors

Wenfeng Liu

Yong Wu

Jian Wang

Zhongliang Wang

Jinyan Gao

Juanli Yuan

Hongbing Chen

Affiliations

Soon will be listed here.

Abstract

Wheat allergy is a primary disease of food allergy, and its global prevalence is unclear. This study aimed to characterize the latest worldwide prevalence of wheat allergy based on five different diagnostic methods. Study searches were conducted in Web of Science, PubMed, Ovid LWW, and Cochrane database, with a time limit of 1 January 2007 to 1 September 2022. The review and screening of the articles was undertaken by two independent reviewers. The statistical analysis was conducted by R. A total of 56 articles were finally included. The prevalence of wheat allergy was 0.63% (95% CI: 0.43-0.87%) for self-reported, 0.70% (95% CI: 0.18-1.22%) for self-reported physician-diagnosed, 0.22% (95%CI: 0.07-0.65%) for skin prick test positive, 0.97% (95% CI: 0.43-2.20%) for specific immunoglobulin E positive, and 0.04% (95% CI: 0-0.16%) for food challenge. However, food challenge can be largely subjective, and the results were only based two countries, so the prevalence of wheat allergy confirmed by food challenge may be not entirely trustworthy. In conclusion, investigating the prevalence of wheat allergy in the real world as accurately as possible will contribute to the prevention, management, and risk assessment of wheat allergy.

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References

Gupta R, Warren C, Smith B, Jiang J, Blumenstock J, Davis M . Prevalence and Severity of Food Allergies Among US Adults. JAMA Netw Open. 2019; 2(1):e185630. PMC: 6324316. DOI: 10.1001/jamanetworkopen.2018.5630. View

Soller L, Ben-Shoshan M, Harrington D, Fragapane J, Joseph L, St Pierre Y . Overall prevalence of self-reported food allergy in Canada. J Allergy Clin Immunol. 2012; 130(4):986-8. DOI: 10.1016/j.jaci.2012.06.029. View

Lao-Araya M, Trakultivakorn M . Prevalence of food allergy among preschool children in northern Thailand. Pediatr Int. 2011; 54(2):238-43. DOI: 10.1111/j.1442-200X.2011.03544.x. View

Yamamoto-Hanada K, Pak K, Saito-Abe M, Yang L, Sato M, Irahara M . Allergy and immunology in young children of Japan: The JECS cohort. World Allergy Organ J. 2020; 13(11):100479. PMC: 7652713. DOI: 10.1016/j.waojou.2020.100479. View

Vierk K, Koehler K, Fein S, Street D . Prevalence of self-reported food allergy in American adults and use of food labels. J Allergy Clin Immunol. 2007; 119(6):1504-10. DOI: 10.1016/j.jaci.2007.03.011. View

Le T, Nguyen D, Vu A, Ruethers T, Taki A, Lopata A . A cross-sectional, population-based study on the prevalence of food allergies among children in two different socio-economic regions of Vietnam. Pediatr Allergy Immunol. 2019; 30(3):348-355. DOI: 10.1111/pai.13022. View

Nwaru B, Hickstein L, Panesar S, Roberts G, Muraro A, Sheikh A . Prevalence of common food allergies in Europe: a systematic review and meta-analysis. Allergy. 2014; 69(8):992-1007. DOI: 10.1111/all.12423. View

Cabanillas B . Gluten-related disorders: Celiac disease, wheat allergy, and nonceliac gluten sensitivity. Crit Rev Food Sci Nutr. 2019; 60(15):2606-2621. DOI: 10.1080/10408398.2019.1651689. View

Munn Z, Moola S, Lisy K, Riitano D, Tufanaru C . Methodological guidance for systematic reviews of observational epidemiological studies reporting prevalence and cumulative incidence data. Int J Evid Based Healthc. 2015; 13(3):147-53. DOI: 10.1097/XEB.0000000000000054. View

10.

Althumiri N, Basyouni M, AlMousa N, AlJuwaysim M, Bindhim N, Alqahtani S . Prevalence of Self-Reported Food Allergies and Their Association with Other Health Conditions among Adults in Saudi Arabia. Int J Environ Res Public Health. 2021; 18(1). PMC: 7796440. DOI: 10.3390/ijerph18010347. View

11.

McGowan E, Keet C . Prevalence of self-reported food allergy in the National Health and Nutrition Examination Survey (NHANES) 2007-2010. J Allergy Clin Immunol. 2013; 132(5):1216-1219.e5. PMC: 3822433. DOI: 10.1016/j.jaci.2013.07.018. View

12.

Lee K, Rha Y, Oh I, Choi Y, Choi S . Socioeconomic and sociodemographic factors related to allergic diseases in Korean adolescents based on the Seventh Korea Youth Risk Behavior Web-based Survey: a cross-sectional study. BMC Pediatr. 2016; 16:19. PMC: 4728782. DOI: 10.1186/s12887-016-0549-2. View

13.

Dean T, Venter C, Pereira B, Arshad S, Grundy J, Clayton C . Patterns of sensitization to food and aeroallergens in the first 3 years of life. J Allergy Clin Immunol. 2007; 120(5):1166-71. DOI: 10.1016/j.jaci.2007.06.042. View

14.

Venter C, Maslin K, Zhang H, Kaushal A, Terry W, Patil V . Use of cluster analysis to characterize patterns of sensitization in childhood allergy. Pediatr Allergy Immunol. 2018; 29(6):644-648. DOI: 10.1111/pai.12925. View

15.

Lyons S, Burney P, Ballmer-Weber B, Fernandez-Rivas M, Barreales L, Clausen M . Food Allergy in Adults: Substantial Variation in Prevalence and Causative Foods Across Europe. J Allergy Clin Immunol Pract. 2019; 7(6):1920-1928.e11. DOI: 10.1016/j.jaip.2019.02.044. View

16.

Grimshaw K, Bryant T, Oliver E, Martin J, Maskell J, Kemp T . Incidence and risk factors for food hypersensitivity in UK infants: results from a birth cohort study. Clin Transl Allergy. 2016; 6:1. PMC: 4727377. DOI: 10.1186/s13601-016-0089-8. View

17.

Nachshon L, Schwartz N, Elizur A, Schon Y, Cheryomukhin M, Katz Y . The Prevalence of Food Allergy in Young Israeli Adults. J Allergy Clin Immunol Pract. 2019; 7(8):2782-2789.e4. DOI: 10.1016/j.jaip.2019.05.046. View

18.

Ostblom E, Lilja G, Ahlstedt S, van Hage M, Wickman M . Patterns of quantitative food-specific IgE-antibodies and reported food hypersensitivity in 4-year-old children. Allergy. 2007; 63(4):418-24. DOI: 10.1111/j.1398-9995.2007.01575.x. View

19.

Hu Y, Chen J, Li H . Comparison of food allergy prevalence among Chinese infants in Chongqing, 2009 versus 1999. Pediatr Int. 2010; 52(5):820-4. DOI: 10.1111/j.1442-200X.2010.03166.x. View

20.

Li J, Ogorodova L, Mahesh P, Wang M, Fedorova O, Leung T . Comparative Study of Food Allergies in Children from China, India, and Russia: The EuroPrevall-INCO Surveys. J Allergy Clin Immunol Pract. 2019; 8(4):1349-1358.e16. DOI: 10.1016/j.jaip.2019.11.042. View