Abnormal Metabolic Connectivity in Default Mode Network of Right Temporal Lobe Epilepsy

Overview

Journal Front Neurosci

Date 2023 Apr 10

PMID 37034164

Authors

Xiaoyang Wang

Dandan Lin

Chunlei Zhao

Hui Li

Liyuan Fu

Zhifeng Huang

Shangwen Xu

Affiliations

Soon will be listed here.

Abstract

Aims: Temporal lobe epilepsy (TLE) is a common neurological disorder associated with the dysfunction of the default mode network (DMN). Metabolic connectivity measured by 18F-fluorodeoxyglucose Positron Emission Computed Tomography (18F-FDG PET) has been widely used to assess cumulative energy consumption and provide valuable insights into the pathophysiology of TLE. However, the metabolic connectivity mechanism of DMN in TLE is far from fully elucidated. The present study investigated the metabolic connectivity mechanism of DMN in TLE using 18F-FDG PET.

Method: Participants included 40 TLE patients and 41 health controls (HC) who were age- and gender-matched. A weighted undirected metabolic network of each group was constructed based on 14 primary volumes of interest (VOIs) in the DMN, in which Pearson's correlation coefficients between each pair-wise of the VOIs were calculated in an inter-subject manner. Graph theoretic analysis was then performed to analyze both global (global efficiency and the characteristic path length) and regional (nodal efficiency and degree centrality) network properties.

Results: Metabolic connectivity in DMN showed that regionally networks changed in the TLE group, including bilateral posterior cingulate gyrus, right inferior parietal gyrus, right angular gyrus, and left precuneus. Besides, significantly decreased ( < 0.05, FDR corrected) metabolic connections of DMN in the TLE group were revealed, containing bilateral hippocampus, bilateral posterior cingulate gyrus, bilateral angular gyrus, right medial of superior frontal gyrus, and left inferior parietal gyrus.

Conclusion: Taken together, the present study demonstrated the abnormal metabolic connectivity in DMN of TLE, which might provide further insights into the understanding the dysfunction mechanism and promote the treatment for TLE patients.

Citing Articles

FDG-PET-based brain network analysis: a brief review of metabolic connectivity.

Tuan P, Adel M, Trung N, Horowitz T, Parlak I, Guedj E EJNMMI Rep. 2025; 9(1):4.

PMID: 39828812 PMC: 11743410. DOI: 10.1186/s41824-024-00232-6.

Individual metabolic brain network abnormalities associated with drug-resistant mTLE vary in surgical outcomes.

Wang X, Zhang P, Lin D, Zhao C, Huang Z, Chen Z Front Neurol. 2025; 15:1444787.

PMID: 39744116 PMC: 11688404. DOI: 10.3389/fneur.2024.1444787.

Dynamic functional connectivity and gene expression correlates in temporal lobe epilepsy: insights from hidden markov models.

Qin L, Zhou Q, Sun Y, Pang X, Chen Z, Zheng J J Transl Med. 2024; 22(1):763.

PMID: 39143498 PMC: 11323657. DOI: 10.1186/s12967-024-05580-2.

References

Zhou S, Xiong P, Ren H, Tan W, Yan Y, Gao Y . Aberrant dorsal attention network homogeneity in patients with right temporal lobe epilepsy. Epilepsy Behav. 2020; 111:107278. DOI: 10.1016/j.yebeh.2020.107278. View

Wang K, Hu W, Liu T, Zhao X, Han C, Xia X . Metabolic covariance networks combining graph theory measuring aberrant topological patterns in mesial temporal lobe epilepsy. CNS Neurosci Ther. 2018; 25(3):396-408. PMC: 6488969. DOI: 10.1111/cns.13073. View

Wang J, Wang X, Xia M, Liao X, Evans A, He Y . GRETNA: a graph theoretical network analysis toolbox for imaging connectomics. Front Hum Neurosci. 2015; 9:386. PMC: 4485071. DOI: 10.3389/fnhum.2015.00386. View

Trimmel K, van Graan A, Caciagli L, Haag A, Koepp M, Thompson P . Left temporal lobe language network connectivity in temporal lobe epilepsy. Brain. 2018; 141(8):2406-2418. DOI: 10.1093/brain/awy164. View

Cui W, Wang Y, Ren J, Hubbard C, Fu X, Fang S . Personalized fMRI Delineates Functional Regions Preserved within Brain Tumors. Ann Neurol. 2022; 91(3):353-366. PMC: 9107064. DOI: 10.1002/ana.26303. View

Zhong J, Guan X, Zhong X, Cao F, Gu Q, Guo T . Levodopa imparts a normalizing effect on default-mode network connectivity in non-demented Parkinson's disease. Neurosci Lett. 2019; 705:159-166. DOI: 10.1016/j.neulet.2019.04.042. View

Ito Y, Fukuda M, Matsuzawa H, Masuda H, Kobayashi Y, Hasegawa N . Deep learning-based diagnosis of temporal lobe epilepsy associated with hippocampal sclerosis: An MRI study. Epilepsy Res. 2021; 178:106815. DOI: 10.1016/j.eplepsyres.2021.106815. View

Ashburner J . SPM: a history. Neuroimage. 2011; 62(2):791-800. PMC: 3480642. DOI: 10.1016/j.neuroimage.2011.10.025. View

Tang Y, Liao G, Li J, Long T, Li Y, Feng L . FDG-PET Profiles of Extratemporal Metabolism as a Predictor of Surgical Failure in Temporal Lobe Epilepsy. Front Med (Lausanne). 2021; 7:605002. PMC: 7793721. DOI: 10.3389/fmed.2020.605002. View

10.

Lu J, Yang Q, Zhang H, Eslinger P, Zhang X, Wu S . Disruptions of the olfactory and default mode networks in Alzheimer's disease. Brain Behav. 2019; 9(7):e01296. PMC: 6625464. DOI: 10.1002/brb3.1296. View

11.

Li D, Liu R, Wang X, Xiong P, Ren H, Wei Y . Abnormal ventral attention network homogeneity in patients with right temporal lobe epilepsy. Eur Rev Med Pharmacol Sci. 2021; 25(4):2031-2038. DOI: 10.26355/eurrev_202102_25107. View

12.

Chiesa P, Cavedo E, Vergallo A, Lista S, Potier M, Habert M . Differential default mode network trajectories in asymptomatic individuals at risk for Alzheimer's disease. Alzheimers Dement. 2019; 15(7):940-950. DOI: 10.1016/j.jalz.2019.03.006. View

13.

Bruner E, Preuss T, Chen X, Rilling J . Evidence for expansion of the precuneus in human evolution. Brain Struct Funct. 2016; 222(2):1053-1060. PMC: 4930733. DOI: 10.1007/s00429-015-1172-y. View

14.

Lu H, Zou Q, Gu H, Raichle M, Stein E, Yang Y . Rat brains also have a default mode network. Proc Natl Acad Sci U S A. 2012; 109(10):3979-84. PMC: 3309754. DOI: 10.1073/pnas.1200506109. View

15.

Franciotti R, Delli Pizzi S, Russo M, Carrarini C, Carrozzino D, Perfetti B . Somatic symptoms disorders in Parkinson's disease are related to default mode and salience network dysfunction. Neuroimage Clin. 2019; 23:101932. PMC: 6658828. DOI: 10.1016/j.nicl.2019.101932. View

16.

Rousseau P, Malbos E, Verger A, Nicolas F, Lancon C, Khalfa S . Increase of precuneus metabolism correlates with reduction of PTSD symptoms after EMDR therapy in military veterans: an 18F-FDG PET study during virtual reality exposure to war. Eur J Nucl Med Mol Imaging. 2019; 46(9):1817-1821. DOI: 10.1007/s00259-019-04360-1. View

17.

Zhang R, Volkow N . Brain default-mode network dysfunction in addiction. Neuroimage. 2019; 200:313-331. DOI: 10.1016/j.neuroimage.2019.06.036. View

18.

McCormick C, Protzner A, Barnett A, Cohn M, Valiante T, McAndrews M . Linking DMN connectivity to episodic memory capacity: what can we learn from patients with medial temporal lobe damage?. Neuroimage Clin. 2014; 5:188-96. PMC: 4110351. DOI: 10.1016/j.nicl.2014.05.008. View

19.

Cho K, Park K, Lee H, Cho H, Lee D, Heo K . Metabolic network is related to surgical outcome in temporal lobe epilepsy with hippocampal sclerosis: A brain FDG-PET study. J Neuroimaging. 2021; 32(2):300-313. DOI: 10.1111/jon.12941. View

20.

Gao Y, Zheng J, Li Y, Guo D, Wang M, Cui X . Abnormal default-mode network homogeneity in patients with temporal lobe epilepsy. Medicine (Baltimore). 2018; 97(26):e11239. PMC: 6039636. DOI: 10.1097/MD.0000000000011239. View