Control of RNA Degradation in Cell Fate Decision

Overview

Journal Front Cell Dev Biol

Specialty Cell Biology

Date 2023 Apr 7

PMID 37025171

Authors

Mingqiang Deng

Xiwei Wang

Zhi Xiong

Peng Tang

Affiliations

Soon will be listed here.

Abstract

Cell fate is shaped by a unique gene expression program, which reflects the concerted action of multilayered precise regulation. Substantial research attention has been paid to the contribution of RNA biogenesis to cell fate decisions. However, increasing evidence shows that RNA degradation, well known for its function in RNA processing and the surveillance of aberrant transcripts, is broadly engaged in cell fate decisions, such as maternal-to-zygotic transition (MZT), stem cell differentiation, or somatic cell reprogramming. In this review, we first look at the diverse RNA degradation pathways in the cytoplasm and nucleus. Then, we summarize how selective transcript clearance is regulated and integrated into the gene expression regulation network for the establishment, maintenance, and exit from a special cellular state.

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