Frequent Transitions in Mating-type Locus Chromosomal Organization in and Early Steps in Sexual Reproduction

Overview

Journal bioRxiv

Date 2023 Mar 30

PMID 36993584

Authors

Marco A Coelho

Giuseppe Ianiri

Marcia David-Palma

Bart Theelen

Rohit Goyal

Aswathy Narayanan

Jeffrey M Lorch

Kaustuv Sanyal

Teun Boekhout

Joseph Heitman

Affiliations

Soon will be listed here.

Abstract

Significance Statement: , the dominant fungal group of the mammalian skin microbiome, is associated with numerous skin disorders. Sexual development and yeast-to-hyphae transitions, governed by genes at two mating-type ( ) loci, are thought to be important for fungal pathogenicity. However, sexual reproduction has never been observed. Here, we used chromosome-level assemblies and comparative genomics to uncover unforeseen transitions in loci organization within , possibly related with fragility of centromeric-associated regions. Additionally, by expressing different alleles in the same cell, we show that can undergo hyphal development and this phenotype is associated with increased expression of key mating genes along with other genes known to be virulence factors, providing a possible connection between hyphal development, sexual reproduction, and pathogenicity.

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