Convergent Evolution of Chromosomal Sex-determining Regions in the Animal and Fungal Kingdoms

Overview

Journal PLoS Biol

Specialty Biology

Date 2004 Nov 13

PMID 15538538

Citations 122

Authors

James A Fraser

Stephanie Diezmann

Ryan L Subaran

Andria Allen

Klaus B Lengeler

Fred S Dietrich

Joseph Heitman

Affiliations

Soon will be listed here.

Abstract

Sexual identity is governed by sex chromosomes in plants and animals, and by mating type (MAT) loci in fungi. Comparative analysis of the MAT locus from a species cluster of the human fungal pathogen Cryptococcus revealed sequential evolutionary events that fashioned this large, highly unusual region. We hypothesize that MAT evolved via four main steps, beginning with acquisition of genes into two unlinked sex-determining regions, forming independent gene clusters that then fused via chromosomal translocation. A transitional tripolar intermediate state then converted to a bipolar system via gene conversion or recombination between the linked and unlinked sex-determining regions. MAT was subsequently subjected to intra- and interallelic gene conversion and inversions that suppress recombination. These events resemble those that shaped mammalian sex chromosomes, illustrating convergent evolution in sex-determining structures in the animal and fungal kingdoms.

Citing Articles

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Distinct effect of calorie restriction between congenic mating types of Cryptococcus neoformans.

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