Early Vascular Changes After Silicone Oil Removal Using Optical Coherence Tomography Angiography

Overview

Journal BMC Ophthalmol

Publisher Biomed Central

Specialty Ophthalmology

Date 2023 Mar 29

PMID 36991349

Authors

Yanan Hou

Lei Liu

Gang Wang

Junwei Xie

Yi Wang

Affiliations

Soon will be listed here.

Abstract

Background: This study evaluated the vascular changes in the macular and peripapillary regions before and after silicone oil (SO) removal in patients with rhegmatogenous retinal detachment.

Methods: This single-center case series assessed patients who underwent SO removal at one hospital. Patients who underwent pars plana vitrectomy and perfluoropropane gas tamponade (PPV + CF) were selected as controls. Superficial vessel density (SVD) and superficial perfusion density (SPD) in the macular and peripapillary regions were assessed by optical coherence tomography angiography (OCTA). Best-corrected visual acuity (BCVA) was assessed using LogMAR.

Results: Fifty eyes were administered SO tamponade, 54 SO tamponade(SOT) contralateral eyes, 29 PPV + CF eyes, and 27 PPV + CF contralateral eyes were selected. SVD and SPD in the macular region were lower in eyes administered SO tamponade compared with SOT contralateral eyes (P < 0.01). Except for the central area, SVD and SPD in the other areas of the peripapillary region were reduced after SO tamponade without SO removal (P < 0.01). No significant differences were found in SVD and SPD between PPV + CF contralateral and PPV + CF eyes. After SO removal, macular SVD and SPD showed significant improvements compared with preoperative values, but no improvements in SVD and SPD were observed in the peripapillary region. BCVA (LogMAR) decreased post-operation and was negatively correlated with macular SVD and SPD.

Conclusions: SVD and SPD are decreased during SO tamponade and increased in the macular region of eyes that underwent SO removal, suggesting a possible mechanism for reduced visual acuity during or after SO tamponade.

Trial Registration: Registration date: 22/05/2019; Registration number, ChiCTR1900023322; Registration site, Chinese Clinical Trial Registry (ChiCTR).

Citing Articles

Retinal vascular changes after Silicon Oil removal in the Eye with Rhegmatogenous Retinal detachment.

Salehi A, Malekahmadi M, Karimi A, Beni A Int J Retina Vitreous. 2024; 10(1):68.

PMID: 39350305 PMC: 11440900. DOI: 10.1186/s40942-024-00587-9.

Macular and Optic Disc Perfusion Changes After Silicone Oil Removal Using Optical Coherence Tomography Angiography: A Prospective Study.

Karakosta C, Verykios V, Feretzakis G, Kourentis C Cureus. 2024; 16(3):e56442.

PMID: 38638747 PMC: 11024882. DOI: 10.7759/cureus.56442.

References

Yang W, Yuan Y, Zong Y, Huang Z, Mai S, Li Y . Preliminary study on retinal vascular and oxygen-related changes after long-term silicone oil and foldable capsular vitreous body tamponade. Sci Rep. 2014; 4:5272. PMC: 4053724. DOI: 10.1038/srep05272. View

Garcia-Ayuso D, Salinas-Navarro M, Agudo-Barriuso M, Alarcon-Martinez L, Vidal-Sanz M, Villegas-Perez M . Retinal ganglion cell axonal compression by retinal vessels in light-induced retinal degeneration. Mol Vis. 2011; 17:1716-33. PMC: 3130728. View

Christensen U, La Cour M . Visual loss after use of intraocular silicone oil associated with thinning of inner retinal layers. Acta Ophthalmol. 2011; 90(8):733-7. DOI: 10.1111/j.1755-3768.2011.02248.x. View

Xiang W, Wei Y, Chi W, Zhang Z, Zhong L, Liu R . Effect of silicone oil on macular capillary vessel density and thickness. Exp Ther Med. 2020; 19(1):729-734. PMC: 6923741. DOI: 10.3892/etm.2019.8243. View

Asaria R, Kon C, Bunce C, Sethi C, Limb G, Khaw P . Silicone oil concentrates fibrogenic growth factors in the retro-oil fluid. Br J Ophthalmol. 2004; 88(11):1439-42. PMC: 1772397. DOI: 10.1136/bjo.2003.040402. View

Winter M, Eberhardt W, Scholz C, Reichenbach A . Failure of potassium siphoning by Müller cells: a new hypothesis of perfluorocarbon liquid-induced retinopathy. Invest Ophthalmol Vis Sci. 2000; 41(1):256-61. View

Lou B, Yuan Z, He L, Lin L, Gao Q, Lin X . The Changes of Retinal Saturation after Long-Term Tamponade with Silicone Oil. Biomed Res Int. 2015; 2015:713828. PMC: 4628732. DOI: 10.1155/2015/713828. View

Odrobina D, Golebiewska J, Maroszynska I . CHOROIDAL THICKNESS CHANGES AFTER VITRECTOMY WITH SILICONE OIL TAMPONADE FOR PROLIFERATIVE VITREORETINOPATHY RETINAL DETACHMENT. Retina. 2016; 37(11):2124-2129. DOI: 10.1097/IAE.0000000000001437. View

Scheerlinck L, Schellekens P, Liem A, Steijns D, van Leeuwen R . INCIDENCE, RISK FACTORS, AND CLINICAL CHARACTERISTICS OF UNEXPLAINED VISUAL LOSS AFTER INTRAOCULAR SILICONE OIL FOR MACULA-ON RETINAL DETACHMENT. Retina. 2015; 36(2):342-50. DOI: 10.1097/IAE.0000000000000711. View

10.

Zhang X, Iverson S, Tan O, Huang D . Effect of Signal Intensity on Measurement of Ganglion Cell Complex and Retinal Nerve Fiber Layer Scans in Fourier-Domain Optical Coherence Tomography. Transl Vis Sci Technol. 2015; 4(5):7. PMC: 4594467. DOI: 10.1167/tvst.4.5.7. View

11.

Yoshikawa Y, Shoji T, Kanno J, Ibuki H, Ozaki K, Ishii H . Evaluation of microvascular changes in the macular area of eyes with rhegmatogenous retinal detachment without macular involvement using swept-source optical coherence tomography angiography. Clin Ophthalmol. 2018; 12:2059-2067. PMC: 6197233. DOI: 10.2147/OPTH.S177933. View

12.

Pichi F, Hay S, Abboud E . Inner retinal toxicity due to silicone oil: a case series and review of the literature. Int Ophthalmol. 2020; 40(9):2413-2422. DOI: 10.1007/s10792-020-01418-0. View

13.

Adelman R, Parnes A, Sipperley J, Ducournau D . Strategy for the management of complex retinal detachments: the European vitreo-retinal society retinal detachment study report 2. Ophthalmology. 2013; 120(9):1809-13. DOI: 10.1016/j.ophtha.2013.01.056. View

14.

Bonfiglio V, Ortisi E, Scollo D, Reibaldi M, Russo A, Pizzo A . Vascular changes after vitrectomy for rhegmatogenous retinal detachment: optical coherence tomography angiography study. Acta Ophthalmol. 2019; 98(5):e563-e569. DOI: 10.1111/aos.14315. View

15.

Gonvers M, Hornung J, De Courten C . The effect of liquid silicone on the rabbit retina. Histologic and ultrastructural study. Arch Ophthalmol. 1986; 104(7):1057-62. DOI: 10.1001/archopht.1986.01050190115049. View

16.

Woo J, Yoon Y, Woo J, Min J . Foveal Avascular Zone Area Changes Analyzed Using OCT Angiography after Successful Rhegmatogenous Retinal Detachment Repair. Curr Eye Res. 2018; 43(5):674-678. DOI: 10.1080/02713683.2018.1437922. View

17.

Lu Y, Chan Y, Lau L, Chao Y, Shih K, Lai S . Adhesion of silicone oil and emulsification: an in vitro assessment using a microfluidic device and 'Eye-on-a-Chip'. Acta Ophthalmol. 2018; 97(3):313-318. DOI: 10.1111/aos.13982. View

18.

Szurman P, Roters S, Grisanti S, Aisenbrey S, Rohrbach J, Warga M . Primary silicone oil tamponade in the management of severe intraocular foreign body injuries: an 8-year follow-up. Retina. 2007; 27(3):304-11. DOI: 10.1097/01.iae.0000237685.99713.83. View

19.

Dogramaci M, Williams K, Lee E, Williamson T . Foveal light exposure is increased at the time of removal of silicone oil with the potential for phototoxicity. Graefes Arch Clin Exp Ophthalmol. 2012; 251(1):35-9. DOI: 10.1007/s00417-012-2033-5. View

20.

Lee S, Han J, Byeon S, Kim S, Koh H, Lee S . RETINAL LAYER SEGMENTATION AFTER SILICONE OIL OR GAS TAMPONADE FOR MACULA-ON RETINAL DETACHMENT USING OPTICAL COHERENCE TOMOGRAPHY. Retina. 2017; 38(2):310-319. DOI: 10.1097/IAE.0000000000001533. View