Alteration of Gut Microbes in Benign Prostatic Hyperplasia Model and Finasteride Treatment Model

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2023 Mar 29

PMID 36982979

Authors

Jinho An

Youngcheon Song

Sangbum Kim

Hyunseok Kong

Kyungjae Kim

Affiliations

Soon will be listed here.

Abstract

Gut microbes are closely associated with disease onset and improvement. However, the effects of gut microbes on the occurrence, prevention, and treatment of benign prostatic hyperplasia (BPH) are still unclear. We investigated the alteration of gut microbiota with implications for the diagnosis, prevention, and treatment of BPH and identified correlations among various indicators, including hormone indicators, apoptosis markers in BPH, and finasteride treatment models. BPH induction altered the abundance of , , , , , , and genera, which are related to BPH indicators. Among these, the altered abundance of and was associated with the promotion and inhibition of prostate apoptosis, respectively. Finasteride treatment altered the abundance of , , , , , and genera, which are related to BPH indicators. Among these, altered abundances of and were associated with the promotion and inhibition of prostate apoptosis, respectively. In addition, the abundances of and were normalized after finasteride treatment. In conclusion, the association between apoptosis and altered abundances of and , among other gut microbes, suggests their potential utility in the diagnosis, prevention, and treatment of BPH.

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