The Gut Microbiome in Health and in Disease

Overview

Journal Curr Opin Gastroenterol

Specialty Gastroenterology

Date 2014 Nov 14

PMID 25394236

Citations 716

Authors

Andrew B Shreiner

John Y Kao

Vincent B Young

Affiliations

Soon will be listed here.

Abstract

Purpose Of Review: Recent technological advancements and expanded efforts have led to a tremendous growth in the collective knowledge of the human microbiome. This review will highlight some of the important recent findings in this area of research.

Recent Findings: Studies have described the structure and functional capacity of the bacterial microbiome in the healthy state and in a variety of disease states. Downstream analyses of the functional interactions between the host and its microbiome are starting to provide mechanistic insights into these interactions. These data are anticipated to lead to new opportunities for diagnosis, prognosis, and treatment of a variety of human diseases.

Summary: There is a fast growing collection of data describing the structure and functional capacity of the microbiome in a variety of conditions available to the research community for consideration and further exploration. Ongoing efforts to further characterize the functions of the microbiome and the mechanisms underlying host-microbe interactions will provide a better understanding of the role of the microbiome in health and disease.

Citing Articles

Altered diversity and composition of gut microbiota in Korean children with food allergy.

Jung M, Lee J, Kim S, Song J, Jang S, Shin S Clin Transl Allergy. 2025; 15(3):e70036.

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Tryptophan and Its Metabolite Serotonin Impact Metabolic and Mental Disorders via the Brain-Gut-Microbiome Axis: A Focus on Sex Differences.

Xu M, Zhou E, Shi H Cells. 2025; 14(5).

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Association of Longitudinal Oral Microbiome Activity and Pediatric Concussion Recovery.

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The Potential Role of Microbiota in Age-Related Cognitive Decline: A Narrative Review of the Underlying Molecular Mechanisms.

Olejnik P, Golenia A, Malyszko J Int J Mol Sci. 2025; 26(4).

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Probiotics and gut microbiota modulation: implications for skin health and disease management.

Parhizkar E, Vosough P, Baneshi M, Keshavarzi A, Lohrasbi P, Taghizadeh S Arch Microbiol. 2025; 207(3):68.

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