Immune-Onco-Microbiome: A New Revolution for Gynecological Cancers

Overview

Journal Biomedicines

Specialty Biomedical Engineering

Date 2023 Mar 29

PMID 36979761

Authors

Chiara Di Tucci

Ilaria De Vito

Ludovico Muzii

Affiliations

Soon will be listed here.

Abstract

Despite significant advances in understanding the pathogenetic mechanisms underlying gynaecological cancers, these cancers still remain widespread. Recent research points to a possible link between microbiota and cancer, and the most recent attention is focusing on the relationship between the microbiome, the immune system, and cancer. The microbiome diversity can affect carcinogenesis and the patient's immune response, modulating the inflammatory cascade and the severity of adverse events. In this review, we presented the recent evidence regarding microbiome alterations in patients with gynaecological tumours to understand if the link that exists between microbiome, immunity, and cancer can guide the prophylactic, diagnostic, and therapeutic management of gynaecological cancers.

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