The Impact of Motor-Cognitive Dual-Task Training on Physical and Cognitive Functions in Parkinson's Disease

Overview

Journal Brain Sci

Publisher MDPI

Date 2023 Mar 29

PMID 36979247

Authors

Yi Xiao

Tianmi Yang

Huifang Shang

Affiliations

Soon will be listed here.

Abstract

Rehabilitation is a high-potential approach to improving physical and cognitive functions in Parkinson's disease (PD). Dual-task training innovatively combines motor and cognitive rehabilitation in a comprehensive module. Patients perform motor and cognitive tasks at the same time in dual-task training. The previous studies of dual-task training in PD had high heterogeneity and achieved controversial results. In the current review, we aim to summarize the current evidence of the effect of dual-task training on motor and cognitive functions in PD patients to support the clinical practice of dual-task training. In addition, we also discuss the current opinions regarding the mechanism underlying the interaction between motor and cognitive training. In conclusion, dual-task training is suitable for PD patients with varied disease duration to improve their motor function. Dual-task training can improve motor symptoms, single-task gait speed, single-task steep length, balance, and objective experience of freezing of gait in PD. The improvement in cognitive function after dual-task training is mild.

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References

Fok P, Farrell M, McMeeken J . The effect of dividing attention between walking and auxiliary tasks in people with Parkinson's disease. Hum Mov Sci. 2011; 31(1):236-46. DOI: 10.1016/j.humov.2011.05.002. View

Fabel K, Wolf S, Ehninger D, Babu H, Leal-Galicia P, Kempermann G . Additive effects of physical exercise and environmental enrichment on adult hippocampal neurogenesis in mice. Front Neurosci. 2010; 3:50. PMC: 2858601. DOI: 10.3389/neuro.22.002.2009. View

Angelucci F, Peppe A, Carlesimo G, Serafini F, Zabberoni S, Barban F . A pilot study on the effect of cognitive training on BDNF serum levels in individuals with Parkinson's disease. Front Hum Neurosci. 2015; 9:130. PMC: 4360779. DOI: 10.3389/fnhum.2015.00130. View

Wu T, Liu J, Zhang H, Hallett M, Zheng Z, Chan P . Attention to Automatic Movements in Parkinson's Disease: Modified Automatic Mode in the Striatum. Cereb Cortex. 2014; 25(10):3330-42. PMC: 4598818. DOI: 10.1093/cercor/bhu135. View

Cameron I, Watanabe M, Pari G, Munoz D . Executive impairment in Parkinson's disease: response automaticity and task switching. Neuropsychologia. 2010; 48(7):1948-57. DOI: 10.1016/j.neuropsychologia.2010.03.015. View

Canning C, Ada L, Woodhouse E . Multiple-task walking training in people with mild to moderate Parkinson's disease: a pilot study. Clin Rehabil. 2008; 22(3):226-33. DOI: 10.1177/0269215507082341. View

Kempermann G, Gast D, Gage F . Neuroplasticity in old age: sustained fivefold induction of hippocampal neurogenesis by long-term environmental enrichment. Ann Neurol. 2002; 52(2):135-43. DOI: 10.1002/ana.10262. View

Killane I, Fearon C, Newman L, McDonnell C, Waechter S, Sons K . Dual Motor-Cognitive Virtual Reality Training Impacts Dual-Task Performance in Freezing of Gait. IEEE J Biomed Health Inform. 2015; 19(6):1855-61. DOI: 10.1109/JBHI.2015.2479625. View

Vuckovic M, Li Q, Fisher B, Nacca A, Leahy R, Walsh J . Exercise elevates dopamine D2 receptor in a mouse model of Parkinson's disease: in vivo imaging with [¹⁸F]fallypride. Mov Disord. 2010; 25(16):2777-84. PMC: 3273304. DOI: 10.1002/mds.23407. View

10.

Wu T, Liu J, Hallett M, Zheng Z, Chan P . Cerebellum and integration of neural networks in dual-task processing. Neuroimage. 2012; 65:466-75. PMC: 4173076. DOI: 10.1016/j.neuroimage.2012.10.004. View

11.

Feng Y, Yang S, Tan Z, Wang M, Xing Y, Dong F . The benefits and mechanisms of exercise training for Parkinson's disease. Life Sci. 2020; 245:117345. DOI: 10.1016/j.lfs.2020.117345. View

12.

Machado S, Teixeira D, Monteiro D, Imperatori C, Murillo-Rodriguez E, da Silva Rocha F . Clinical applications of exercise in Parkinson's disease: what we need to know?. Expert Rev Neurother. 2022; 22(9):771-780. DOI: 10.1080/14737175.2022.2128768. View

13.

Walsh J, Tschakovsky M . Exercise and circulating BDNF: Mechanisms of release and implications for the design of exercise interventions. Appl Physiol Nutr Metab. 2018; 43(11):1095-1104. DOI: 10.1139/apnm-2018-0192. View

14.

Schabrun S, Lamont R, Brauer S . Transcranial Direct Current Stimulation to Enhance Dual-Task Gait Training in Parkinson's Disease: A Pilot RCT. PLoS One. 2016; 11(6):e0158497. PMC: 4928827. DOI: 10.1371/journal.pone.0158497. View

15.

Ali N, Tian H, Thabane L, Ma J, Wu H, Zhong Q . The Effects of Dual-Task Training on Cognitive and Physical Functions in Older Adults with Cognitive Impairment; A Systematic Review and Meta-Analysis. J Prev Alzheimers Dis. 2022; 9(2):359-370. DOI: 10.14283/jpad.2022.16. View

16.

Penko A, Barkley J, Rosenfeldt A, Alberts J . Multimodal Training Reduces Fall Frequency as Physical Activity Increases in Individuals With Parkinson's Disease. J Phys Act Health. 2019; 16(12):1085-1091. DOI: 10.1123/jpah.2018-0595. View

17.

Radder D, Silva de Lima A, Domingos J, Keus S, van Nimwegen M, Bloem B . Physiotherapy in Parkinson's Disease: A Meta-Analysis of Present Treatment Modalities. Neurorehabil Neural Repair. 2020; 34(10):871-880. PMC: 7564288. DOI: 10.1177/1545968320952799. View

18.

Strouwen C, Molenaar E, Munks L, Broeder S, Ginis P, Bloem B . Determinants of Dual-Task Training Effect Size in Parkinson Disease: Who Will Benefit Most?. J Neurol Phys Ther. 2018; 43(1):3-11. DOI: 10.1097/NPT.0000000000000247. View

19.

Fortaleza A, Mancini M, Carlson-Kuhta P, King L, Nutt J, Chagas E . Dual task interference on postural sway, postural transitions and gait in people with Parkinson's disease and freezing of gait. Gait Posture. 2017; 56:76-81. PMC: 5714292. DOI: 10.1016/j.gaitpost.2017.05.006. View

20.

Schaeffer E, Roeben B, Granert O, Hanert A, Liepelt-Scarfone I, Leks E . Effects of exergaming on hippocampal volume and brain-derived neurotrophic factor levels in Parkinson's disease. Eur J Neurol. 2021; 29(2):441-449. DOI: 10.1111/ene.15165. View