Advances in Mass Spectrometry-Based Single Cell Analysis

Overview

Journal Biology (Basel)

Publisher MDPI

Specialty Biology

Date 2023 Mar 29

PMID 36979087

Authors

Siheun Lee

Hung M Vu

Jung-Hyun Lee

Heejin Lim

Min-Sik Kim

Affiliations

Soon will be listed here.

Abstract

Technological developments and improvements in single-cell isolation and analytical platforms allow for advanced molecular profiling at the single-cell level, which reveals cell-to-cell variation within the admixture cells in complex biological or clinical systems. This helps to understand the cellular heterogeneity of normal or diseased tissues and organs. However, most studies focused on the analysis of nucleic acids (e.g., DNA and RNA) and mass spectrometry (MS)-based analysis for proteins and metabolites of a single cell lagged until recently. Undoubtedly, MS-based single-cell analysis will provide a deeper insight into cellular mechanisms related to health and disease. This review summarizes recent advances in MS-based single-cell analysis methods and their applications in biology and medicine.

Citing Articles

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