Arabic Gum Ameliorates Systemic Modulation in Alloxan Monohydrate-induced Diabetic Rats

Overview

Journal Sci Rep

Specialty Science

Date 2023 Mar 27

PMID 36973339

Authors

Rasha Mohammed Ibrahim

Hemmat Mansour Abdelhafez

Sawsan Abd El-Maksoud El-Shamy

Fatma Ahmed Eid

Alya Mashaal

Affiliations

Soon will be listed here.

Abstract

Medicinal plants are considered an alternative therapy for diabetes mellitus as they regulate glucose levels. Moreover, a variety of plants offer a rich source of bioactive compounds that have potent pharmacological effects without any negative side effects. The present study aimed to clarify the effects of Arabic gum/Gum Acacia (GA) on the biochemical, histopathological, and immunohistochemical changes observed in diabetic rats. Further, the anti-inflammatory activity of GA in response to diabetes, through inflammatory mediators analysis. Male rats were divided into four groups: untreated control, diabetic, Arabic gum-treated, and Arabic gum-treated diabetic rats. Diabetes was induced using alloxan. Animals were sacrificed after 7 and 21 days of treatment with Arabic gum. Body weight, blood and pancreas tissue samples were collected for analysis. Alloxan injection significantly decreased body weight, increased glucose levels, decreased insulin levels, and caused depletion of islets of Langerhans and β-cell damage in the pancreas. Arabic gum treatment of diabetic rats significantly increased body weight, decreased serum glucose levels, increased insulin levels, exerts anti-inflammatory effect, and improved the pancreas tissue structure. Arabic gum has beneficial pharmacological effects in diabetic rats; therefore, it might be employed as diabetic therapy to reduce the hyperglycemic damage and may be applicable for many autoimmune and inflammatory diseases treatment. Further, the new bioactive substances, such as medications made from plants, have larger safety margins, and can be used for a longer period of time.

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References

Chandalia M, Garg A, Lutjohann D, von Bergmann K, Grundy S, Brinkley L . Beneficial effects of high dietary fiber intake in patients with type 2 diabetes mellitus. N Engl J Med. 2000; 342(19):1392-8. DOI: 10.1056/NEJM200005113421903. View

Cocchetto D, Bjornsson T . Methods for vascular access and collection of body fluids from the laboratory rat. J Pharm Sci. 1983; 72(5):465-92. DOI: 10.1002/jps.2600720503. View

Kuang Y, Chai Y, Su H, Lo J, Qiao X, Ye M . A network pharmacology-based strategy to explore the pharmacological mechanisms of Antrodia camphorata and antcin K for treating type II diabetes mellitus. Phytomedicine. 2021; 96:153851. DOI: 10.1016/j.phymed.2021.153851. View

Babio N, Balanza R, Basulto J, Bullo M, Salas-Salvado J . Dietary fibre: influence on body weight, glycemic control and plasma cholesterol profile. Nutr Hosp. 2010; 25(3):327-40. View

Lenzen S . The mechanisms of alloxan- and streptozotocin-induced diabetes. Diabetologia. 2007; 51(2):216-26. DOI: 10.1007/s00125-007-0886-7. View

Cieslak M, Wojtczak A, Cieslak M . Role of pro-inflammatory cytokines of pancreatic islets and prospects of elaboration of new methods for the diabetes treatment. Acta Biochim Pol. 2015; 62(1):15-21. DOI: 10.18388/abp.2014_853. View

Devi N, Sarmah M, Khatun B, Maji T . Encapsulation of active ingredients in polysaccharide-protein complex coacervates. Adv Colloid Interface Sci. 2016; 239:136-145. DOI: 10.1016/j.cis.2016.05.009. View

Asad M, Aslam M, Munir T, Nadeem A . Effect of Acacia nilotica leaves extract on hyperglycaemia, lipid profile and platelet aggregation in streptozotocin induced diabetic rats. J Ayub Med Coll Abbottabad. 2014; 23(2):3-7. View

Zamstein O, Sheiner E, Wainstock T, Landau D, Walfisch A . Maternal gestational diabetes and long-term respiratory related hospitalizations of the offspring. Diabetes Res Clin Pract. 2018; 140:200-207. DOI: 10.1016/j.diabres.2018.03.050. View

10.

Coskun O, Kanter M, Korkmaz A, Oter S . Quercetin, a flavonoid antioxidant, prevents and protects streptozotocin-induced oxidative stress and beta-cell damage in rat pancreas. Pharmacol Res. 2005; 51(2):117-23. DOI: 10.1016/j.phrs.2004.06.002. View

11.

Tangvarasittichai S . Oxidative stress, insulin resistance, dyslipidemia and type 2 diabetes mellitus. World J Diabetes. 2015; 6(3):456-80. PMC: 4398902. DOI: 10.4239/wjd.v6.i3.456. View

12.

Eliza J, Daisy P, Ignacimuthu S, Duraipandiyan V . Antidiabetic and antilipidemic effect of eremanthin from Costus speciosus (Koen.)Sm., in STZ-induced diabetic rats. Chem Biol Interact. 2009; 182(1):67-72. DOI: 10.1016/j.cbi.2009.08.012. View

13.

Dymkowska D, Drabarek B, Podszywalow-Bartnicka P, Szczepanowska J, Zablocki K . Hyperglycaemia modifies energy metabolism and reactive oxygen species formation in endothelial cells in vitro. Arch Biochem Biophys. 2013; 542:7-13. DOI: 10.1016/j.abb.2013.11.008. View

14.

Shawky L, Morsi A, El Bana E, Hanafy S . The Biological Impacts of Sitagliptin on the Pancreas of a Rat Model of Type 2 Diabetes Mellitus: Drug Interactions with Metformin. Biology (Basel). 2019; 9(1). PMC: 7167819. DOI: 10.3390/biology9010006. View

15.

Matough F, Budin S, Hamid Z, Alwahaibi N, Mohamed J . The role of oxidative stress and antioxidants in diabetic complications. Sultan Qaboos Univ Med J. 2012; 12(1):5-18. PMC: 3286717. DOI: 10.12816/0003082. View

16.

Ighodaro O, Adeosun A, Akinloye O . Alloxan-induced diabetes, a common model for evaluating the glycemic-control potential of therapeutic compounds and plants extracts in experimental studies. Medicina (Kaunas). 2018; 53(6):365-374. DOI: 10.1016/j.medici.2018.02.001. View

17.

Hegazy G, Alnoury A, Gad H . The role of Acacia Arabica extract as an antidiabetic, antihyperlipidemic, and antioxidant in streptozotocin-induced diabetic rats. Saudi Med J. 2013; 34(7):727-33. View

18.

Halban P, Polonsky K, Bowden D, Hawkins M, Ling C, Mather K . β-cell failure in type 2 diabetes: postulated mechanisms and prospects for prevention and treatment. J Clin Endocrinol Metab. 2014; 99(6):1983-92. PMC: 5393482. DOI: 10.1210/jc.2014-1425. View

19.

Abd El Hady Mousa M, Mansour H, Eid F, Mashaal A . Anti-inflammatory activity of ginger modulates macrophage activation against the inflammatory pathway of monosodium glutamate. J Food Biochem. 2021; :e13819. DOI: 10.1111/jfbc.13819. View

20.

Ali B, Ziada A, Blunden G . Biological effects of gum arabic: a review of some recent research. Food Chem Toxicol. 2008; 47(1):1-8. DOI: 10.1016/j.fct.2008.07.001. View