Oxidative Stress, Insulin Resistance, Dyslipidemia and Type 2 Diabetes Mellitus

Overview

Journal World J Diabetes

Publisher Baishideng Publishing Group

Specialty Endocrinology

Date 2015 Apr 22

PMID 25897356

Citations 398

Authors

Surapon Tangvarasittichai

Affiliations

Soon will be listed here.

Abstract

Oxidative stress is increased in metabolic syndrome and type 2 diabetes mellitus (T2DM) and this appears to underlie the development of cardiovascular disease, T2DM and diabetic complications. Increased oxidative stress appears to be a deleterious factor leading to insulin resistance, dyslipidemia, β-cell dysfunction, impaired glucose tolerance and ultimately leading to T2DM. Chronic oxidative stress, hyperglycemia and dyslipidemia are particularly dangerous for β-cells from lowest levels of antioxidant, have high oxidative energy requirements, decrease the gene expression of key β-cell genes and induce cell death. If β-cell functioning is impaired, it results in an under production of insulin, impairs glucose stimulated insulin secretion, fasting hyperglycemia and eventually the development of T2DM.

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References

Peelman F, Waelput W, Iserentant H, Lavens D, Eyckerman S, Zabeau L . Leptin: linking adipocyte metabolism with cardiovascular and autoimmune diseases. Prog Lipid Res. 2004; 43(4):283-301. DOI: 10.1016/j.plipres.2004.03.001. View

Steinberg D, Parthasarathy S, Carew T, Khoo J, Witztum J . Beyond cholesterol. Modifications of low-density lipoprotein that increase its atherogenicity. N Engl J Med. 1989; 320(14):915-24. DOI: 10.1056/NEJM198904063201407. View

Hennig B, Meerarani P, Ramadass P, Watkins B, Toborek M . Fatty acid-mediated activation of vascular endothelial cells. Metabolism. 2000; 49(8):1006-13. DOI: 10.1053/meta.2000.7736. View

Estrada D, Ewart H, Tsakiridis T, Volchuk A, Ramlal T, Tritschler H . Stimulation of glucose uptake by the natural coenzyme alpha-lipoic acid/thioctic acid: participation of elements of the insulin signaling pathway. Diabetes. 1996; 45(12):1798-804. DOI: 10.2337/diab.45.12.1798. View

Pal P, Sinha K, Sil P . Mangiferin, a natural xanthone, protects murine liver in Pb(II) induced hepatic damage and cell death via MAP kinase, NF-κB and mitochondria dependent pathways. PLoS One. 2013; 8(2):e56894. PMC: 3581562. DOI: 10.1371/journal.pone.0056894. View

West I . Radicals and oxidative stress in diabetes. Diabet Med. 2000; 17(3):171-80. DOI: 10.1046/j.1464-5491.2000.00259.x. View

Ogihara T, Asano T, Ando K, Chiba Y, Sakoda H, Anai M . Angiotensin II-induced insulin resistance is associated with enhanced insulin signaling. Hypertension. 2002; 40(6):872-9. DOI: 10.1161/01.hyp.0000040262.48405.a8. View

Staruchova M, Collins A, Volkovova K, Mislanova C, Kovacikova Z, Tulinska J . Occupational exposure to mineral fibres. Biomarkers of oxidative damage and antioxidant defence and associations with DNA damage and repair. Mutagenesis. 2008; 23(4):249-60. DOI: 10.1093/mutage/gen004. View

Bulcao C, Ribeiro-Filho F, Sanudo A, Roberta Ferreira S . Effects of simvastatin and metformin on inflammation and insulin resistance in individuals with mild metabolic syndrome. Am J Cardiovasc Drugs. 2007; 7(3):219-24. DOI: 10.2165/00129784-200707030-00007. View

10.

Ho E, Chen G, Bray T . Supplementation of N-acetylcysteine inhibits NFkappaB activation and protects against alloxan-induced diabetes in CD-1 mice. FASEB J. 1999; 13(13):1845-54. View

11.

Niedernhofer L, Daniels J, Rouzer C, Greene R, Marnett L . Malondialdehyde, a product of lipid peroxidation, is mutagenic in human cells. J Biol Chem. 2003; 278(33):31426-33. DOI: 10.1074/jbc.M212549200. View

12.

Annuk M, Zilmer M, Fellstrom B . Endothelium-dependent vasodilation and oxidative stress in chronic renal failure: impact on cardiovascular disease. Kidney Int Suppl. 2003; (84):S50-3. DOI: 10.1046/j.1523-1755.63.s84.2.x. View

13.

Wojtczak L, Schonfeld P . Effect of fatty acids on energy coupling processes in mitochondria. Biochim Biophys Acta. 1993; 1183(1):41-57. DOI: 10.1016/0005-2728(93)90004-y. View

14.

Reilly M, Iqbal N, Schutta M, Wolfe M, Scally M, Russell Localio A . Plasma leptin levels are associated with coronary atherosclerosis in type 2 diabetes. J Clin Endocrinol Metab. 2004; 89(8):3872-8. DOI: 10.1210/jc.2003-031676. View

15.

Ho E, Chen G, Bray T . Alpha-phenyl-tert-butylnitrone (PBN) inhibits NFkappaB activation offering protection against chemically induced diabetes. Free Radic Biol Med. 2000; 28(4):604-14. DOI: 10.1016/s0891-5849(99)00271-3. View

16.

Morrow J, Frei B, Longmire A, Gaziano J, Lynch S, Shyr Y . Increase in circulating products of lipid peroxidation (F2-isoprostanes) in smokers. Smoking as a cause of oxidative damage. N Engl J Med. 1995; 332(18):1198-203. DOI: 10.1056/NEJM199505043321804. View

17.

Dobrian A, Davies M, Schriver S, Lauterio T, Prewitt R . Oxidative stress in a rat model of obesity-induced hypertension. Hypertension. 2001; 37(2 Pt 2):554-60. DOI: 10.1161/01.hyp.37.2.554. View

18.

Verges B . New insight into the pathophysiology of lipid abnormalities in type 2 diabetes. Diabetes Metab. 2005; 31(5):429-39. DOI: 10.1016/s1262-3636(07)70213-6. View

19.

Yamagishi S, Edelstein D, Du X, Kaneda Y, Guzman M, Brownlee M . Leptin induces mitochondrial superoxide production and monocyte chemoattractant protein-1 expression in aortic endothelial cells by increasing fatty acid oxidation via protein kinase A. J Biol Chem. 2001; 276(27):25096-100. DOI: 10.1074/jbc.M007383200. View

20.

Boyle J, Thompson T, Gregg E, Barker L, Williamson D . Projection of the year 2050 burden of diabetes in the US adult population: dynamic modeling of incidence, mortality, and prediabetes prevalence. Popul Health Metr. 2010; 8:29. PMC: 2984379. DOI: 10.1186/1478-7954-8-29. View