Herbal Formula BaWeiBaiDuSan Alleviates Polymicrobial Sepsis-induced Liver Injury Increasing the Gut Microbiota and Regulating Macrophage Anti-inflammatory Activity in Mice

Overview

Journal Acta Pharm Sin B

Publisher Elsevier

Specialty Pharmacology

Date 2023 Mar 27

PMID 36970196

Authors

Xiaoqing Fan

Chutian Mai

Ling Zuo

Jumin Huang

Chun Xie

Zebo Jiang

Runze Li

Xiaojun Yao

Xingxing Fan

Qibiao Wu

Peiyu Yan

Liang Liu

Jianxin Chen

Ying Xie

Elaine Lai-Han Leung

Affiliations

Soon will be listed here.

Abstract

Sepsis-induced liver injury (SILI) is an important cause of septicemia deaths. BaWeiBaiDuSan (BWBDS) was extracted from a formula of C. A. , F. E. ex var. , ex , Thunb., Linn., Vas, (Jacq.) A. DC., and . Herein, we investigated whether the BWBDS treatment could reverse SILI by the mechanism of modulating gut microbiota. BWBDS protected mice against SILI, which was associated with promoting macrophage anti-inflammatory activity and enhancing intestinal integrity. BWBDS selectively promoted the growth of in cecal ligation and puncture treated mice. Fecal microbiota transplantation treatment indicated that gut bacteria correlated with sepsis and was required for BWBDS anti-sepsis effects. Notably, significantly reduced SILI by promoting macrophage anti-inflammatory activity, increasing interleukin-10 M2 macrophage production and enhancing intestinal integrity. Furthermore, heat inactivation (HI-) treatment promoted macrophage anti-inflammatory activity and alleviated SILI. Our findings revealed BWBDS and gut microbiota as novel prebiotic and probiotic that may be used to treat SILI. The potential underlying mechanism was at least in part, -dependent immune regulation and interleukin-10 M2 macrophage production.

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