Non-Essential Amino Acid Availability Influences Proteostasis and Breast Cancer Cell Survival During Proteotoxic Stress

Overview

Journal Mol Cancer Res

Specialty Cell Biology

Date 2023 Mar 24

PMID 36961392

Authors

Sara Sannino

Allison M Manuel

Chaowei Shang

Stacy G Wendell

Peter Wipf

Jeffrey L Brodsky

Affiliations

Soon will be listed here.

Abstract

Implications: These data position amino acid abundance, GCN2, mTORC1, and autophagy as integrated therapeutic targets whose coordinated modulation regulates the survival of proteotoxic-resistant breast cancer cells.

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