Synthesis of Novel Sulphamethoxazole Derivatives and Exploration of Their Anticancer and Antimicrobial Properties

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2023 Mar 23

PMID 36952512

Authors

Rita Vaickelioniene

Vilma Petrikaite

Irena Vaskeviciene

Alvydas Pavilonis

Vytautas Mickevicius

Affiliations

Soon will be listed here.

Abstract

A series of new derivatives based on sulfamethoxazole were designed and synthesized in this study. The structures of the new compounds were confirmed based on a comprehensive characterization of spectral data by applied IR and 1H as well as 13C NMR spectroscopy. The prepared compounds were tested for their anticancer and antimicrobial properties. Hydrazone 16b demonstrated convincing anticancer effect against all tested cell cultures such as human prostate carcinoma PPC-1 and human kidney carcinoma CaKi-1 cell lines, and human fibroblasts HF, n = 3. The most promising compound 16b showed higher activity against CaKi-1 cell line than the anticancer drugs axitinib and pazopanib used to treat renal cancer. Also, it was more active in the PPC-1 cell line compared to the approved PARP inhibitor Olaparib. Hydrazone 16b was also found to possess good antimicrobial properties against gram-positive bacteria strains of Staphylococcus aureus, Staphylococcus epidermidis, as well as Bacillus cereus.

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