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Rita Vaickelioniene

Explore the profile of Rita Vaickelioniene including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 13
Citations 28
Followers 0
Related Specialties
Chemistry
Biochemistry
Biology
Top 10 Co-Authors
Vytautas Mickevicius
Birute Grybaite
Povilas Kavaliauskas
Birute Sapijanskaite-Banevic
Vidmantas Petraitis
Ruta Petraitiene
Vilma Petrikaite
Ethan Naing
Jurate Siugzdaite
Andrew Garcia
Published In
Molecules
Int J Mol Sci
Antibiotics (Basel)
Pharmaceuticals (Basel)
Sci Rep
Affiliations
Soon will be listed here.
Recent Articles
1.
Synthesis and effect of 4-acetylphenylamine-based imidazole derivatives on migration and growth of 3D cultures of breast, prostate and brain cancer cells
Golciene B, Vaickelioniene R, Endriulaityte U, Mickevicius V, Petrikaite V
Sci Rep . 2024 Nov; 14(1):28065. PMID: 39543257
In this study, we have synthesized novel 4-acetophenone moiety-bearing functionalized imidazole derivatives containing S-, and N-ethyl substituents and evaluated their anticancer activity. Their anticancer activity was studied against human breast...
2.
Synthesis of 3-((4-Hydroxyphenyl)amino)propanoic Acid Derivatives as Promising Scaffolds for the Development of Antimicrobial Candidates Targeting Multidrug-Resistant Bacterial and Fungal Pathogens
Kavaliauskas P, Grybaite B, Sapijanskaite-Banevic B, Vaickelioniene R, Petraitis V, Petraitiene R, et al.
Antibiotics (Basel) . 2024 Feb; 13(2). PMID: 38391579
Infections caused by multidrug-resistant bacterial and fungal pathogens represent a significant global health concern, contributing to increased morbidity and mortality rates. Therefore, it is crucial to develop novel compounds targeting...
3.
The Effect of 4-(Dimethylamino)phenyl-5-oxopyrrolidines on Breast and Pancreatic Cancer Cell Colony Formation, Migration, and Growth of Tumor Spheroids
Kairyte K, Vaickelioniene R, Grybaite B, Anusevicius K, Mickevicius V, Petrikaite V
Int J Mol Sci . 2024 Feb; 25(3). PMID: 38339112
A series of hydrazones, azoles, and azines bearing a 4-dimethylaminophenyl-5-oxopyrrolidine scaffold was synthesized. Their cytotoxic effect against human pancreatic carcinoma Panc-1 and triple-negative breast cancer MDA-MB-231 cell lines was established...
4.
Synthesis of 1-(2-Hydroxyphenyl)- and (3,5-Dichloro-2-hydroxyphenyl)-5-oxopyrrolidine-3-carboxylic Acid Derivatives as Promising Scaffolds for the Development of Novel Antimicrobial and Anticancer Agents
Bertasiute M, Kavaliauskas P, Vaickelioniene R, Grybaite B, Petraitis V, Petraitiene R, et al.
Int J Mol Sci . 2023 May; 24(9). PMID: 37175673
Increasing antimicrobial resistance among Gram-positive pathogens and pathogenic fungi remains one of the major public healthcare threats. Therefore, novel antimicrobial candidates and scaffolds are critically needed to overcome resistance in...
5.
Synthesis of novel sulphamethoxazole derivatives and exploration of their anticancer and antimicrobial properties
Vaickelioniene R, Petrikaite V, Vaskeviciene I, Pavilonis A, Mickevicius V
PLoS One . 2023 Mar; 18(3):e0283289. PMID: 36952512
A series of new derivatives based on sulfamethoxazole were designed and synthesized in this study. The structures of the new compounds were confirmed based on a comprehensive characterization of spectral...
6.
Synthesis and Development of -2,5-Dimethylphenylthioureido Acid Derivatives as Scaffolds for New Antimicrobial Candidates Targeting Multidrug-Resistant Gram-Positive Pathogens
Kavaliauskas P, Grybaite B, Vaickelioniene R, Sapijanskaite-Banevic B, Anusevicius K, Kriauciunaite A, et al.
Antibiotics (Basel) . 2023 Feb; 12(2). PMID: 36830130
The growing antimicrobial resistance to last-line antimicrobials among Gram-positive pathogens remains a major healthcare emergency worldwide. Therefore, the search for new small molecules targeting multidrug-resistant pathogens remains of great importance....
7.
Synthesis and Biological Activity Characterization of Novel 5-Oxopyrrolidine Derivatives with Promising Anticancer and Antimicrobial Activity
Kairyte K, Grybaite B, Vaickelioniene R, Sapijanskaite-Banevic B, Kavaliauskas P, Mickevicius V
Pharmaceuticals (Basel) . 2022 Aug; 15(8). PMID: 36015119
The 1-(4-acetamidophenyl)-5-oxopyrrolidine carboxylic acid was applied for synthesizing derivatives bearing azole, diazole, and hydrazone moieties in the molecule. Modification of an acetamide fragment to the free amino group afforded compounds...
8.
Synthesis of Novel Aminothiazole Derivatives as Promising Antiviral, Antioxidant and Antibacterial Candidates
Minickaite R, Grybaite B, Vaickelioniene R, Kavaliauskas P, Petraitis V, Petraitiene R, et al.
Int J Mol Sci . 2022 Jul; 23(14). PMID: 35887038
It is well-known that thiazole derivatives are usually found in lead structures, which demonstrate a wide range of pharmacological effects. The aim of this research was to explore the antiviral,...
9.
Synthesis of Novel Thiazole Derivatives Bearing β-Amino Acid and Aromatic Moieties as Promising Scaffolds for the Development of New Antibacterial and Antifungal Candidates Targeting Multidrug-Resistant Pathogens
Malukaite D, Grybaite B, Vaickelioniene R, Vaickelionis G, Sapijanskaite-Banevic B, Kavaliauskas P, et al.
Molecules . 2022 Jan; 27(1). PMID: 35011308
Rapidly growing antimicrobial resistance among clinically important bacterial and fungal pathogens accounts for high morbidity and mortality worldwide. Therefore, it is critical to look for new small molecules targeting multidrug-resistant...
10.
Evaluation of N-aryl-β-alanine derivatives as anticancer agents in triple-negative breast cancer and glioblastoma in vitro models
Zukauskas M, Grybaite B, Jonute P, Vaickelioniene R, Gibieza P, Vaickelionis G, et al.
Bioorg Chem . 2021 Aug; 115:105214. PMID: 34426161
Synthesis of β-amino acid derivatives containing hydrazone and azole moieties is described. For this purpose, the appropriate hydrazide was treated with aromatic aldehydes, ketones and phenyl iso(thio)cyanates to obtain the...