Tracing Founder Mutations in Circulating and Tissue-Resident Follicular Lymphoma Precursors

Overview

Journal Cancer Discov

Specialty Oncology

Date 2023 Mar 20

PMID 36939219

Authors

Joseph G Schroers-Martin

Joanne Soo

Gabriel Brisou

Florian Scherer

David M Kurtz

Brian J Sworder

Michael S Khodadoust

Michael C Jin

Agnes Bru

Chih Long Liu

Henning Stehr

Paolo Vineis

Yasodha Natkunam

Lauren R Teras

Joo Y Song

Bertrand Nadel

Maximilian Diehn

Sandrine Roulland

Ash A Alizadeh

Affiliations

Soon will be listed here.

Abstract

Significance: Our study provides direct evidence for recurrent genetic aberrations preceding FL diagnosis, revealing the combination of BCL2 translocation with CREBBP KAT domain mutations as characteristic committed lesions of FL CPCs. Such prediagnostic mutations are detectable years before clinical diagnosis and may help discriminate individuals at risk for lymphoma development. This article is highlighted in the In This Issue feature, p. 1275.

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