Retrospective, Multicenter Study of Surgical Treatment for Carotid Body Tumors with or Without Preoperative Embolization

Overview

Journal Front Oncol

Specialty Oncology

Date 2023 Mar 20

PMID 36937387

Authors

Tonglei Han

Jiaxi Pu

Hanfei Tang

Shaofei Yang

Dandan Dong

Minhao Lu

Xiaolong Wei

Guanghua Yang

Bin Zhao

Daqiao Guo

Xiao Tang

Zhiqing Zhao

Affiliations

Soon will be listed here.

Abstract

Background: Carotid body tumor (CBT) is the most common head and neck paraganglioma. Whether preoperative embolization benefits CBT patients who will receive surgical resection is still controversial.

Methods: In this multi-center retrospective study, we collected data from patients with CBT who received surgical treatment without (group A) or with preoperative embolization (group B) from 2011 to 2019. The primary outcome was the rate of death or stroke after 3 years of follow-up. The secondary outcomes of the study were length of operation (LOO), intraoperative blood loss (IBL), length of stay (LOS), rate of recurrence, and rate of cranial nerve (CN) injuries. Descriptive statistics were used to analyze the demographics, clinical characteristics, complications, and follow-up results of the patients.

Results: Between January 2011 and October 2019, 261 consecutive patients (107 male and 154 female) entered analysis. After 3 years of follow-up, no patient died in both groups. Only three patients with stroke were detected: 2/226 (0.9%) in group A vs. 1/35 (2.9%) in group B (p = .308). The LOO in group A was 132.6 ± 64.6 min compared with 152.9 ± 40.4 min in group B (p = .072). IBL in group A was 375.4 ± 497.8 ml compared with 448.0 ± 270.8 ml in group B (p = .400). LOS in group A was 8.3 ± 2.0 days compared with 7.4 ± 1.7 days in group B (p = .016). Seventy-two CN injuries were detected: 65/226 (28.8%) in group A vs. 7/35 (20.0%) in group B (p = .281). There were 65 temporary CN injuries (59 in group A vs. 6 in group B) (p = .254) and seven permanent CN injuries (6 in group A vs. 1 in group B) (p = .945). Three most frequently injured cranial nerves were the pharyngeal branch and superior laryngeal nerve (12.3%), recurrent laryngeal nerve (7.7%) and vagus nerve (7.3%).

Conclusion: There was insufficient evidence to support the efficacy of preoperative embolization. CBT resection alone had a similar rate of stoke, recurrence, and CN injuries when compared with CBT resection with preoperative arterial embolization. Meanwhile, CBT resection alone did not increase LOO and IBL.

Citing Articles

Head and Neck Paragangliomas: 16-year Single-center Experience and Mini Review on Diagnosis, Treatment, and Follow-up.

Aydemir G, Ardic F, Kara C, Bir F Medeni Med J. 2024; 39(3):192-203.

PMID: 39350541 PMC: 11572209. DOI: 10.4274/MMJ.galenos.2024.91668.

Preoperative Direct Puncture Embolization Using a Nonadhesive Ethylene Vinyl Alcohol (EVOH) Liquid Embolic Agent for Head and Neck Paragangliomas.

Alexandre A, Scarcia L, Clarencon F, Camilli A, Bartolo A, Incandela F Clin Neuroradiol. 2023; 34(2):307-314.

PMID: 38066106 DOI: 10.1007/s00062-023-01364-1.

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